Iwai J, Heine M
J Hypertens Suppl. 1986 Oct;4(3):S29-31.
At Brookhaven we have two new strains of rats with opposing genetic predispositions to hypertension: one strain [inbred Dahl salt-sensitive (Dahl-S)] develops severe hypertension on a high-salt diet, while the other [inbred Dahl salt-resistant (Dahl-R)] responds only mildly, if at all. The striking observation is that, unlike other salt-sensitive hypertension-prone rats, inbred Dahl-S rats remain normotensive on a low-salt diet. The observation that hypertension in the inbred Dahl-S, but not the inbred Dahl-R, rat develops only after exposure to a high-salt diet indicates that the development of hypertension in the inbred Dahl-S strain is not spontaneous and that the genetic substrate is a critical determinant of the hazard of excess salt in the diet.
在布鲁克海文国家实验室，我们培育出了两种具有相反高血压遗传倾向的新型大鼠品系：一种品系[近交系达尔盐敏感型（Dahl-S）]在高盐饮食下会发展为严重高血压，而另一种品系[近交系达尔盐抵抗型（Dahl-R）]即便有反应也只是轻微反应。引人注目的是，与其他易患盐敏感性高血压的大鼠不同，近交系达尔盐敏感型大鼠在低盐饮食下血压仍保持正常。近交系达尔盐敏感型大鼠而非近交系达尔盐抵抗型大鼠的高血压仅在接触高盐饮食后才会出现，这一观察结果表明，近交系达尔盐敏感型品系中高血压的发展并非自发的，而且遗传基础是饮食中过量盐分危害的关键决定因素。
