Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, No. 227, Yanta West Road, Yanta district, Xi'an, Shaanxi, 86-710061, People's Republic of China.
Department of Emergency, Xi'an Children's Hospital, Xi'an, Shaanxi, 86-710061, People's Republic of China.
Respir Res. 2021 Mar 22;22(1):89. doi: 10.1186/s12931-020-01577-9.
Thise study is aimed to identify the biomarkers for predicting refractory Mycoplasma pneumoniae pneumonia in Chinese children at the time of the hospital admission.
The case control study retrospectively analyzed the clinical characteristics and laboratory results of Chinese pediatric patients presenting with common and refractory Mycoplasma pneumoniae pneumonia (CMPP and RMPP). Overall, there were 216 cases in the CMPP group and 88 cases in the RMPP group. Venous blood was collected, and serum ferritin (SF), lactate dehydrogenase (LDH), D-dimer, C-reactive protein (CRP), procalcitonin (PCT), neutrophil count/lymphocyte count (NLR), and other indexes were measured. A single factor analysis, an ROC curve analysis, and a logistic regression analysis were used to determine the independent risk factors of RMPP and find combination of initial markers for RMPP.
There were significant differences between the RMPP group and the CMPP group in mean SF (529.82 [357.86] vs. 147.22 [122.68] ng/mL), LDH (522.08 [389.08] vs. 286.85 [101.02] U/L), D-dimer (6.65 [5.66] vs. 1.46 [2.45] μg/mL), CRP (62.80 [52.15] vs. 19.03 [24.50] mg/L), PCT (0.80 [2.61] vs. 0.16 [0.44]) ng/mL, and NLR (4.14 [2.52] vs. 2.62 [1.55]), with P < 0.05 for each comparison. ROC cut-off values of the above indexes were 329.01 ng/mL, 375.50 U/L, 2.10 μg/mL, 43.08 mg/L, 0.08 ng/mL, and 2.96, respectively. The logistic regression analysis showed that SF, D-dimer, and CRP are independent risk factors to predict RMPP.
SF, D-dimer, and CRP are statistically significant biomarkers to predict RMPP in Chinese children patients in the settings of pediatric emergency department.
本研究旨在确定中国儿童入院时预测难治性肺炎支原体肺炎（RMPP）的生物标志物。
采用回顾性病例对照研究，分析中国儿童普通型（CMPP）和难治型肺炎支原体肺炎（RMPP）患儿的临床特征和实验室结果。共纳入 216 例 CMPP 患儿和 88 例 RMPP 患儿。采集静脉血，检测血清铁蛋白（SF）、乳酸脱氢酶（LDH）、D-二聚体、C 反应蛋白（CRP）、降钙素原（PCT）、中性粒细胞/淋巴细胞比值（NLR）等指标。采用单因素分析、ROC 曲线分析和 logistic 回归分析确定 RMPP 的独立危险因素，并寻找 RMPP 的初始标志物组合。
RMPP 组与 CMPP 组的 SF（529.82[357.86] vs. 147.22[122.68]ng/ml）、LDH（522.08[389.08] vs. 286.85[101.02]U/L）、D-二聚体（6.65[5.66] vs. 1.46[2.45]μg/ml）、CRP（62.80[52.15] vs. 19.03[24.50]mg/L）、PCT（0.80[2.61] vs. 0.16[0.44]ng/ml）和 NLR（4.14[2.52] vs. 2.62[1.55]）差异有统计学意义（P<0.05）。上述指标的 ROC 曲线下面积截断值分别为 329.01ng/ml、375.50U/L、2.10μg/ml、43.08mg/L、0.08ng/ml 和 2.96。logistic 回归分析显示，SF、D-二聚体和 CRP 是预测 RMPP 的独立危险因素。
SF、D-二聚体和 CRP 是中国儿科急诊患儿 RMPP 的统计学显著生物标志物。
