Chen Xiaoli, Wang Shanhu, Cai Hailun, Xia Xiaojiao
Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wen Zhou, Zhe Jiang, China.
Epidemiol Infect. 2024 Dec 5;152:e158. doi: 10.1017/S0950268824001134.
This cohort study evaluated the associations of C-reactive protein-neutrophil to lymphocyte ratio (C-NLR) and lymphocyte-CRP ratio (LCR) with refractory Mycoplasma pneumoniae pneumonia (RMPP), and the predictive values of C-NLR and LCR for RMPP and prolonged fever in children based on 389 children with MPP. The associations of NLR, C-NLR, and LCR with RMPP and prolonged fever were evaluated by logistic regression analysis. C-NLR was correlated with an increased risk of RMPP in children [odds ratio (OR) = 3.459, 95% confidence interval (CI): 1.598-7.491]. A higher risk of RMPP was identified in the C-NLR > 29.9 group (OR = 2.885, 95% CI: 1.599-5.203). LCR > 1584.2 was associated with a decreased risk of RMPP (OR = 0.500, 95% CI: 0.282-0.887). Increased risk of prolonged fever in children was identified with the increase of C-NLR (OR = 5.913, 95% CI: 2.335-14.972) or NLR (OR = 2.413, 95% CI: 1.689-3.446). The AUCs of C-NLR, LCR, and NLR for predicting RMPP were 0.630, 0.623, and 0.608, respectively. In conclusion, C-NLR was associated with increased RMPP risk in children and had good value for predicting RMPP and prolonged fever in children.
这项队列研究基于389例支原体肺炎（MPP）患儿，评估了C反应蛋白-中性粒细胞与淋巴细胞比值（C-NLR）和淋巴细胞-CRP比值（LCR）与难治性支原体肺炎（RMPP）的相关性，以及C-NLR和LCR对儿童RMPP和持续发热的预测价值。通过逻辑回归分析评估NLR、C-NLR和LCR与RMPP及持续发热的相关性。C-NLR与儿童RMPP风险增加相关[比值比（OR）=3.459，95%置信区间（CI）：1.598-7.491]。C-NLR>29.9组的RMPP风险更高（OR=2.885，95%CI：1.599-5.203）。LCR>1584.2与RMPP风险降低相关（OR=0.500，95%CI：0.282-0.887）。随着C-NLR（OR=5.913，95%CI：2.335-14.972）或NLR（OR=2.413，95%CI：1.689-3.446）升高，儿童持续发热风险增加。C-NLR、LCR和NLR预测RMPP的曲线下面积（AUC）分别为0.630、0.623和0.608。总之，C-NLR与儿童RMPP风险增加相关，对预测儿童RMPP和持续发热具有良好价值。
