甲状腺功能减退女性的甲状腺自身免疫与卵巢储备之间的关联。
Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism.
作者信息
Morales-Martínez Felipe A, Sordia-Hernández Luis H, Ruiz Martha Merino, Garcia-Luna Selene, Valdés-Martínez Otto H, Vidal-Gutierez Oscar
机构信息
Centro Universitario de Medicina Reproductiva, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León. Monterrey, Edificio Rodrigo Barragán 3er piso Ave., Av. Francisco I. Madero s/n y Gonzalitos Col. Mitras Centro, NL, C.P. 64460, Monterrey, Mexico.
Departamento de Ginecología y Obstetricia, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, NL, Monterrey, México.
出版信息
Thyroid Res. 2021 Mar 22;14(1):6. doi: 10.1186/s13044-021-00095-0.
BACKGROUND
The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto's thyroiditis (HT) is the most common in women of reproductive age. Furthermore, a prolonged reduction in thyroid hormone concentration results in a broad spectrum of reproductive alteration. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve. Thus, this prospective and comparative study aimed to evaluate the association of hypothyroidism with low ovarian reserve.
MATERIALS AND METHODS
A subset of 27 patients with primary autoimmune hypothyroidism were compared to healthy women. The ovarian reserve was assessed through the anti-Mullerian hormone (AMH) and the antral follicle count (AFC).
RESULTS
Overall, the two groups did not display significant differences in length of their menstrual cycles neither in the AMH serum levels nor the AFC.
CONCLUSIONS
No significant alteration was found in the ovarian reserve of women with HT.
背景
自身免疫性疾病的发病机制可能会损害卵巢功能，进而影响卵巢储备，其中桥本甲状腺炎（HT）在育龄女性中最为常见。此外，甲状腺激素浓度的长期降低会导致广泛的生殖功能改变。以往文献报道中，关于甲状腺功能减退与卵巢储备改变的影响存在争议。因此，本前瞻性比较研究旨在评估甲状腺功能减退与低卵巢储备之间的关联。
材料与方法
将27例原发性自身免疫性甲状腺功能减退患者的子集与健康女性进行比较。通过抗苗勒管激素（AMH）和窦卵泡计数（AFC）评估卵巢储备。
结果
总体而言，两组在月经周期长度、AMH血清水平和AFC方面均未显示出显著差异。
结论
未发现HT女性的卵巢储备有明显改变。
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