Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Kotani Tomomi, Kikkawa Fumitaka
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Maternal and Perinatal Medicine, Nagoya University Hospital, Nagoya, Japan.
Horm Metab Res. 2018 Jul;50(7):537-542. doi: 10.1055/a-0637-9430. Epub 2018 Jul 10.
Patients with primary ovarian insufficiency (POI) have a high prevalence of thyroid autoimmune disorders. However, the extent of the contribution of thyroid autoantibodies or elevated thyroid-stimulating hormone (TSH) levels to decreased ovarian reserve is unclear. Therefore, we evaluated the serum levels of anti-Müllerian hormone (AMH) and thyroid autoantibodies [antithyroperoxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb)] in euthyroid infertile women. One hundred and fifty-three women with normal menstrual cycles were recruited for this retrospective study. Serum levels of AMH were compared between patients with positive and negative thyroid autoantibodies. The correlation between serum levels of AMH and each thyroid autoantibody was also evaluated. Participants were observed to be either TPOAb or TgAb positive (n=27), only TPOAb positive (n=8), only TgAb positive (n=7), TPOAb and TgAb positive (double positive; n=12), and TPOAb and TgAb negative (double negative; n=126). No significant differences were found in serum AMH levels between the TPOAb- or TgAb-positive women and the antibody-double negative women. Serum AMH levels did not show a significant correlation with the concentration of TgAb or TPOAb. On the other hand, serum AMH levels negatively correlated with TSH levels in patients who were either positive for TPOAb or TgAb. Thyroid autoantibodies are not likely to influence ovarian reserve in euthyroid women whose TSH levels fall within the normal range although elevated TSH levels may be involved in the decline of serum AMH levels.
原发性卵巢功能不全（POI）患者甲状腺自身免疫性疾病的患病率很高。然而，甲状腺自身抗体或促甲状腺激素（TSH）水平升高对卵巢储备功能下降的影响程度尚不清楚。因此，我们评估了甲状腺功能正常的不孕女性血清中抗苗勒管激素（AMH）及甲状腺自身抗体[抗甲状腺过氧化物酶抗体（TPOAb）和抗甲状腺球蛋白抗体（TgAb）]的水平。本回顾性研究招募了153名月经周期正常的女性。比较了甲状腺自身抗体阳性和阴性患者的血清AMH水平。还评估了血清AMH水平与每种甲状腺自身抗体之间的相关性。参与者被观察为TPOAb或TgAb阳性（n=27）、仅TPOAb阳性（n=8）、仅TgAb阳性（n=7）、TPOAb和TgAb均阳性（双阳性；n=12）以及TPOAb和TgAb均阴性（双阴性；n=126）。TPOAb或TgAb阳性女性与抗体双阴性女性的血清AMH水平未发现显著差异。血清AMH水平与TgAb或TPOAb的浓度未显示出显著相关性。另一方面，在TPOAb或TgAb阳性的患者中，血清AMH水平与TSH水平呈负相关。甲状腺自身抗体不太可能影响TSH水平在正常范围内的甲状腺功能正常女性的卵巢储备，尽管TSH水平升高可能与血清AMH水平下降有关。
