肾功能储备在预测急性肾损伤中的作用。
The Role of Renal Functional Reserve in Predicting Acute Kidney Injury.
机构信息
Pediatrics, Critical Care Medicine, and Nephrology, Department of Critical Care Medicine, The Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Children's Hospital Drive, Faculty Pavilion, Suite 2000, Pittsburgh, PA 15224, USA.
出版信息
Crit Care Clin. 2021 Apr;37(2):399-407. doi: 10.1016/j.ccc.2020.11.008. Epub 2021 Feb 13.
Abstract
Renal functional reserve (RFR) is described as the difference between a glomerular filtration rate (GFR) measured at baseline and after protein stimulation. The percent change in GFR after a protein load varies based on differences in experimental conditions, with the use of an oral meat protein stimulus and a creatinine clearance method to quantify GFR showing the greatest RFR. A decline in RFR has been found in numerous patient groups. Recent investigations have suggested that a lower RFR may be associated with an increased risk of acute kidney injury and eventual chronic kidney disease.
摘要
肾功能储备（RFR）被描述为在基线和蛋白质刺激后测量的肾小球滤过率（GFR）之间的差异。GFR 在蛋白质负荷后的变化百分比因实验条件的不同而有所不同，使用口服肉蛋白刺激物和肌酐清除率方法来定量 GFR 显示出最大的 RFR。在许多患者群体中发现 RFR 下降。最近的研究表明，较低的 RFR 可能与急性肾损伤和最终慢性肾脏病的风险增加有关。
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