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2019冠状病毒病大流行对香港器官捐赠的影响:一项单中心观察性研究

Impact of COVID-19 Pandemic on Organ Donation in Hong Kong: A Single-Center Observational Study.

作者信息

Cheung Chi Yuen, Pong Mei Lan, Au Yeung Suk Fun, Chak Wai Leung

机构信息

Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR.

Transplant Coordinating Service, Kowloon Central Cluster, Hospital Authority, Hong Kong SAR.

出版信息

Transplant Proc. 2021 May;53(4):1143-1145. doi: 10.1016/j.transproceed.2021.02.016. Epub 2021 Feb 26.

DOI:10.1016/j.transproceed.2021.02.016
PMID:33752902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9757866/
Abstract

INTRODUCTION

The coronavirus disease 2019 (COVID-19) pandemic was expected to have a negative impact on organ donation. With the differences in health care systems and lockdown policies in various regions, the pandemic's effect on organ donation and transplant service may vary. Most of the deceased donor organ referrals in our hospital came from non-intensive care units (ICUs). The objective of this study is to report our experience and quantify the effects of the COVID-19 pandemic on deceased donor organ donation in our center.

METHODS

This was a retrospective observational study comparing the deceased donor organ donation activity during the period January 23 to November 30, 2020 with the same period in 2018 in Queen Elizabeth Hospital, Hong Kong.

RESULTS

There was a 26.9% reduction in deceased donor organ donor referral in 2020 compared with 2018. No significant difference in the proportion of referrals from ICU or non-ICU areas between the 2 time periods was observed. The brain death confirmation rate was significantly higher in 2020 (40.8% vs 20.2%, P = .003). Nine patients had family consent for organ donation in 2020 (vs 7 patients in the same period in 2018). There were no significant differences in consent rate and number of recovered organs between the 2 periods.

CONCLUSIONS

With effective measures to limit the spread of COVID-19 in a community, it is possible to support the needs of both patients with COVID-19 and deceased donor organ donation services.

摘要

引言

2019年冠状病毒病(COVID-19)大流行预计会对器官捐献产生负面影响。由于各地区医疗保健系统和封锁政策存在差异,大流行对器官捐献和移植服务的影响可能有所不同。我院大多数已故捐赠者器官转介来自非重症监护病房(ICU)。本研究的目的是报告我们的经验,并量化COVID-19大流行对我院已故捐赠者器官捐献的影响。

方法

这是一项回顾性观察研究,比较了2020年1月23日至11月30日期间与2018年同期香港伊利沙伯医院已故捐赠者器官捐献活动。

结果

与2018年相比,2020年已故捐赠者器官转介减少了26.9%。两个时间段之间,ICU或非ICU区域转介比例没有显著差异。2020年脑死亡确认率显著更高(40.8%对20.2%,P = 0.003)。2020年有9名患者家属同意器官捐献(2018年同期为7名患者)。两个时间段之间同意率和回收器官数量没有显著差异。

结论

通过采取有效措施限制COVID-19在社区的传播,有可能同时满足COVID-19患者和已故捐赠者器官捐献服务的需求。

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Transplant Proc. 2021 May;53(4):1143-1145. doi: 10.1016/j.transproceed.2021.02.016. Epub 2021 Feb 26.
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本文引用的文献

1
Organ procurement and transplantation in Germany during the COVID-19 pandemic.新冠疫情期间德国的器官获取与移植
Lancet. 2020 Oct 31;396(10260):1395. doi: 10.1016/S0140-6736(20)32213-3.
2
Donation and transplantation activity in the UK during the COVID-19 lockdown.新冠疫情封锁期间英国的捐赠与移植活动。
Lancet. 2020 Aug 15;396(10249):465-466. doi: 10.1016/S0140-6736(20)31692-5.
3
An increase in kidney transplantation procedures from deceased donors during the COVID-19 epidemic in Slovenia.斯洛文尼亚在新冠疫情期间 deceased 捐赠者的肾脏移植手术有所增加。 (注:这里“deceased”常见释义为“已故的”,但结合语境推测这里可能是指“脑死亡等判定为死亡状态的捐赠者”,不过按照要求未添加解释说明)
Transpl Int. 2020 Nov;33(11):1562-1564. doi: 10.1111/tri.13715. Epub 2020 Aug 26.
4
Organ procurement and transplantation during the COVID-19 pandemic.2019冠状病毒病大流行期间的器官获取与移植
Lancet. 2020 May 23;395(10237):e95-e96. doi: 10.1016/S0140-6736(20)31040-0. Epub 2020 May 11.
5
Immediate impact of COVID-19 on transplant activity in the Netherlands.COVID-19 对荷兰器官移植活动的直接影响。
Transpl Immunol. 2020 Aug;61:101304. doi: 10.1016/j.trim.2020.101304. Epub 2020 May 1.
6
What can countries learn from Hong Kong's response to the COVID-19 pandemic?各国能从香港应对新冠疫情的举措中学到什么?
CMAJ. 2020 May 11;192(19):E511-E515. doi: 10.1503/cmaj.200563. Epub 2020 Apr 24.
7
The COVID-19 outbreak in Italy: Initial implications for organ transplantation programs.意大利的 COVID-19 疫情:对器官移植项目的初步影响。
Am J Transplant. 2020 Jul;20(7):1780-1784. doi: 10.1111/ajt.15904. Epub 2020 Apr 17.
8
COVID-19: A global transplant perspective on successfully navigating a pandemic.COVID-19:从全球移植角度成功应对大流行。
Am J Transplant. 2020 Jul;20(7):1773-1779. doi: 10.1111/ajt.15876. Epub 2020 Apr 12.
9
Factors affecting the deceased organ donation rate in the Chinese community: an audit of hospital medical records in Hong Kong.影响华人社区已故器官捐赠率的因素:香港医院病历审计
Hong Kong Med J. 2016 Dec;22(6):570-5. doi: 10.12809/hkmj164930. Epub 2016 Oct 24.