College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, PR China.
School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, PR China.
Pharmacol Res. 2021 May;167:105572. doi: 10.1016/j.phrs.2021.105572. Epub 2021 Mar 20.
Metabolic diseases are becoming increasingly common in modern society. Therefore, it is essential to develop effective drugs or new treatments for metabolic diseases. As an active ingredient derived from plants, celastrol has shown great potential in the treatment of a wide variety of metabolic diseases and received considerable attention in recent years. In reported studies, the anti-obesity effect of celastrol resulted from regulating leptin sensitivity, energy metabolism, inflammation, lipid metabolism and even gut microbiota. Celastrol reversed insulin resistance via multiple routes to protect against type 2 diabetes. Celastrol also showed effects on atherosclerosis, cholestasis and osteoporosis. Celastrol in treating metabolic diseases seem to be versatile and the targets or pathways were diverse. Here, we systematically review the mechanism of action, and the therapeutic properties of celastrol in various metabolic diseases and complications. Based on this review, potential research strategies might contribute to the celastrol's clinical application in the future.
代谢性疾病在现代社会中越来越普遍。因此，开发治疗代谢性疾病的有效药物或新疗法至关重要。作为一种源自植物的活性成分，雷公藤红素在治疗多种代谢性疾病方面显示出巨大的潜力，近年来受到了广泛关注。在已报道的研究中，雷公藤红素的抗肥胖作用是通过调节瘦素敏感性、能量代谢、炎症、脂质代谢甚至肠道微生物群来实现的。雷公藤红素通过多种途径逆转胰岛素抵抗，从而预防 2 型糖尿病。雷公藤红素还对动脉粥样硬化、胆汁淤积和骨质疏松症有作用。雷公藤红素在治疗代谢性疾病方面似乎具有多功能性，其作用靶点或途径多种多样。在这里，我们系统地综述了雷公藤红素在各种代谢性疾病及其并发症中的作用机制和治疗特性。基于这篇综述，潜在的研究策略可能有助于雷公藤红素在未来的临床应用。
