Suppr超能文献

SGLT2i类口服降糖药诱发的糖尿病正常血糖性酮症酸中毒

Diabetic Euglycemic Ketoacidosis Induced by Oral Antidiabetics Type SGLT2i.

作者信息

Velasco de Cos Guillermo, Sánchez-Molina Acosta María Isabel, Fernández María Matilde Toval

机构信息

Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Hospital Comarcal de Laredo, Spain.

出版信息

EJIFCC. 2021 Feb 28;32(1):105-110. eCollection 2021 Feb.

Abstract

Euglycemic diabetic ketoacidosis (euglycemic DKA) is a serious complication of diabetes, which can occur in some patients treated with oral antidiabetics called sodium-glucose co-transporter 2 inhibitors (SGLT2i). This group of drugs works by increasing renal excretion of sodium and glucose, thereby lowering blood glucose levels. Euglycemic DKA is characterized by having blood glucose levels in the normal range, usually below 200 mg/dL (11 mmol/L), which complicates early diagnosis. We present the case of a 67-year-old patient with type 2 diabetes mellitus, treated with metformin and empagliflozin, who was admitted to the Intensive Care Unit in a coma with severe ketoacidotic decompensation.

摘要

正常血糖性糖尿病酮症酸中毒(正常血糖性DKA)是糖尿病的一种严重并发症,可发生于一些使用名为钠-葡萄糖协同转运蛋白2抑制剂(SGLT2i)的口服抗糖尿病药物治疗的患者中。这类药物通过增加肾脏对钠和葡萄糖的排泄起作用,从而降低血糖水平。正常血糖性DKA的特征是血糖水平在正常范围内,通常低于200mg/dL(11mmol/L),这使得早期诊断变得复杂。我们报告一例67岁2型糖尿病患者的病例,该患者接受二甲双胍和恩格列净治疗,因严重酮症酸中毒失代偿昏迷入住重症监护病房。

相似文献

本文引用的文献

5
Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma.正常血糖性糖尿病酮症酸中毒:诊断与治疗难题
Endocrinol Diabetes Metab Case Rep. 2017 Sep 4;2017. doi: 10.1530/EDM-17-0081. eCollection 2017.
7
Euglycemic Diabetic Ketoacidosis: A Review.正常血糖性糖尿病酮症酸中毒:综述
Curr Diabetes Rev. 2017;13(3):315-321. doi: 10.2174/1573399812666160421121307.
9
SGLT2 Inhibitors May Predispose to Ketoacidosis.钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂可能易引发酮症酸中毒。
J Clin Endocrinol Metab. 2015 Aug;100(8):2849-52. doi: 10.1210/jc.2015-1884. Epub 2015 Jun 18.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验