Gorman J M, Goetz R R, Fyer M, King D L, Fyer A J, Liebowitz M R, Klein D F
Department of Radiology, Columbia University, New York, NY 10032.
Psychosom Med. 1988 Mar-Apr;50(2):114-22. doi: 10.1097/00006842-198803000-00002.
Whether mitral valve prolapse (MVP) is more common in patients with panic disorder (PD) and agoraphobia with panic attacks (AgP) than in the normal population is controversial. A related issue is whether the presence of MVP in such patients has any clinical or biological significance. Echocardiograms were performed on 36 patients with PD/AgP and 22 normal controls. MVP was found to be more common in PD/AgP patients than in normal controls. However, MVP in the patients was mild and not associated with thickened mitral leaflets or small left ventricular size. Moderate or severe prolapse was uncommon in both groups. Patients with MVP had trends to higher heart rate and prolonged QTc interval on EKG, and reported more respiratory difficulty during panic attacks compared to patients without MVP. Lactate infusion did not affect patients with MVP differently than patients without MVP. The authors conclude that MVP is more common in patients with PD or AgP than in normal controls, but is of doubtful clinical significance.
二尖瓣脱垂（MVP）在惊恐障碍（PD）和伴有惊恐发作的广场恐惧症（AgP）患者中是否比正常人群更常见存在争议。一个相关问题是，此类患者中MVP的存在是否具有任何临床或生物学意义。对36例PD/AgP患者和22名正常对照者进行了超声心动图检查。发现MVP在PD/AgP患者中比在正常对照者中更常见。然而，患者中的MVP程度较轻，且与二尖瓣叶增厚或左心室较小无关。两组中中度或重度脱垂均不常见。与无MVP的患者相比，有MVP的患者心率有升高趋势，心电图上QTc间期延长，且在惊恐发作时报告有更多呼吸困难。乳酸输注对有MVP的患者和无MVP的患者的影响没有差异。作者得出结论，MVP在PD或AgP患者中比在正常对照者中更常见，但临床意义存疑。
