Tuor U I, Kondysar M H, Harding R K
Division of Biomedical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
Radiat Res. 1988 Jun;114(3):537-49.
We examined the sensitivity of the ferret to emetic stimuli and the effect of radiation exposure near the time of emesis on local cerebral blood flow. Ferrets vomited following the administration of either apomorphine (approx 45% of the ferrets tested) or peptide YY (approx 36% of those tested). Exposure to radiation was a very potent emetic stimulus, but vomiting could be prevented by restraint of the hindquarters of the ferret. Local cerebral blood flow was measured using a quantitative autoradiographic technique and with the exception of several regions in the telencephalon and cerebellum, local cerebral blood flow in the ferret was similar to that in the rat. In animals with whole-body exposure to moderate levels of radiation (4 Gy of 137Cs), mean arterial blood pressure was similar to that in the control group. However, 15-25 min following irradiation there was a general reduction of local cerebral blood flow ranging from 7 to 33% of that in control animals. These cerebral blood flow changes likely correspond to a reduced activation of the central nervous system.
我们研究了雪貂对催吐刺激的敏感性以及呕吐前后附近区域辐射暴露对局部脑血流量的影响。注射阿扑吗啡（约45%受试雪貂）或肽YY（约36%受试雪貂）后，雪貂会出现呕吐。辐射暴露是一种非常有效的催吐刺激，但通过束缚雪貂后肢可防止呕吐。采用定量放射自显影技术测量局部脑血流量，除端脑和小脑的几个区域外，雪貂的局部脑血流量与大鼠相似。全身暴露于中等剂量辐射（4戈瑞的137铯）的动物，其平均动脉血压与对照组相似。然而，照射后15 - 25分钟，局部脑血流量普遍减少，为对照动物的7%至33%。这些脑血流量变化可能与中枢神经系统激活减少有关。
