Khyber Medical University, Peshawar & Institute of Health and Wellbeing, University of Glasgow, UK.
Khyber Medical University, Peshawar.
J Ayub Med Coll Abbottabad. 2020 Oct-Dec;32(Suppl 1)(4):S633-S639.
COVID-19 is an ongoing public health issue across the world. Several risk factors associated with mortality in COVID-19 have been reported. The present study aims to describe clinical and epidemiological characteristics and predictors of mortality in hospitalized patients from Khyber Pakhtunkhwa, a province in Pakistan with highest COVID-19 associated case fatality rate.
This multicentre, retrospective study was conducted in hospitalized COVID-19 patients who died or discharged alive until 1st May 2020. Data about sociodemographic characteristics, clinical and laboratory findings, treatment and outcome were obtained from hospital records and compared between survivors and non-survivors. Statistical tests were applied to determine the risk factors associated with mortality in hospitalized patients.
Of the total 179 patients from the 10 designated hospitals, 127 (70.9%) were discharged alive while 52 (29.1%) died in the hospital. Overall, 109 (60.9%) patients had an underlying comorbidity with hypertension being the commonest. Multivariate logistics regression analysis showed significantly higher odds of in-hospital death from COVID-19 in patients with multiple morbidities (OR 3.2, 95% CI 1.1, 9.1, p-value=0.03), length of hospital stay (OR 0.8, 95% CI 0.7, 0.9, p-value <0.001), those presenting with dyspnoea (OR 4.0, 95% CI 1.1, 14.0, p-value=0.03) and oxygen saturation below 90 (OR 9.6, 95% CI: 3.1, 29.2, p-value <0.001).
Comorbidity, oxygen saturation and dyspnoea on arrival and length of stay in hospital (late admission) are associated with COVID-19 mortality. The demographic, clinical and lab characteristics could potentially help clinician and policy makers before potential second wave in the country.
COVID-19 是全球范围内持续存在的公共卫生问题。已经报道了与 COVID-19 死亡率相关的几个危险因素。本研究旨在描述巴基斯坦开伯尔-普赫图赫瓦省住院患者的临床和流行病学特征以及死亡的预测因素，该省 COVID-19 相关病死率最高。
这是一项多中心、回顾性研究，对象为截至 2020 年 5 月 1 日死亡或出院的住院 COVID-19 患者。从医院记录中获取有关社会人口统计学特征、临床和实验室检查结果、治疗和结局的数据，并在存活者和非存活者之间进行比较。应用统计学检验确定与住院患者死亡相关的危险因素。
在来自 10 家指定医院的 179 名患者中，127 名（70.9%）出院存活，52 名（29.1%）在医院死亡。总体而言，109 名（60.9%）患者有合并症，其中最常见的是高血压。多变量逻辑回归分析显示，患有多种合并症的 COVID-19 患者住院死亡的可能性显著增加（OR 3.2，95%CI 1.1，9.1，p 值=0.03）、住院时间（OR 0.8，95%CI 0.7，0.9，p 值<0.001）、呼吸困难（OR 4.0，95%CI 1.1，14.0，p 值=0.03）和血氧饱和度低于 90%（OR 9.6，95%CI：3.1，29.2，p 值<0.001）。
合并症、入院时的血氧饱和度和呼吸困难以及住院时间（入院较晚）与 COVID-19 死亡率相关。这些人口统计学、临床和实验室特征可能有助于临床医生和决策者在该国可能出现第二波疫情之前做出决策。
