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SARS-CoV2 爆发:人冠状病毒的出现、传播和临床特征。

SARS-CoV2 Outbreak: Emergence, transmission and clinical features of human coronaviruses.

机构信息

College of Physicians & Surgeons Pakistan.

The Indus Hospital, Karachi, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2020 Oct-Dec;32(Suppl 1)(4):S710-S713.

Abstract

The novel coronavirus was emerged from China Wuhan city and spread around the globe within a few days. COVID-19 is rapidly transmitted from one human to another, and it is also a highly pathogenic infection. Genetic analysis confirmed that SARS-CoV 2 is phenotypically related to SARS-CoV; therefore, the possible reservoir for SARS-CoV 2 could be bats. According to WHO more than 20 million individuals infected with SARS-CoV 2 while more than 700,000 peoples lost their lives due to COVID-19 as of 13th August 2020. Up-till now, there is no anti-viral therapy or vaccines available for the treatment and prevention of COVID-19. Although dexamethasone and tocilizumab help in reducing mortality among critical patient infected with COVID-19 However, China, Brazil and USA have developed vaccines which is currently under trial phase. Still, up-till now, there is no clinically approved treatment regimen available against COVID-19.

摘要

新型冠状病毒源自中国武汉市,并在数天内迅速传播至全球。COVID-19 极易在人与人之间传播,同时也是一种高致病性感染。基因分析证实,SARS-CoV-2 在表型上与 SARS-CoV 相关;因此,SARS-CoV-2 的可能宿主可能是蝙蝠。根据世界卫生组织的数据,截至 2020 年 8 月 13 日,全球有超过 2000 万人感染了 SARS-CoV-2,超过 70 万人因 COVID-19 失去了生命。到目前为止,还没有针对 COVID-19 的抗病毒治疗或疫苗。虽然地塞米松和托珠单抗有助于降低 COVID-19 重症患者的死亡率,但中国、巴西和美国已经开发出疫苗,目前正在临床试验阶段。尽管如此,到目前为止,还没有针对 COVID-19 的临床批准的治疗方案。

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