血清内脏脂肪素水平与强直性脊柱炎患者临床参数、血流介导扩张和颈动脉内膜中层厚度的关系。
The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis.
机构信息
Department of Physical Medicine and Rehabilitation, Malatya Training and Research Hospital, Turgut Özal University, Malatya, Turkey
Department of Rheumatology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
出版信息
Turk J Med Sci. 2021 Aug 30;51(4):1865-1874. doi: 10.3906/sag-2012-351.
BACKGROUND/AIM: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS.
MATERIALS AND METHODS
Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods.
RESULTS
Visfatin levels of the patients were significantly higher than controls (p < 0.001). FMD values in patients with AS were significantly lower (p = 0.007) whereas cIMT were significantly higher than the controls (p = 0.003). There was a negative relationship between FMD with visfatin levels (p = 0.004), BASDAI (p = 0.010), and BASFI (p = 0.007). There was a positive relationship between cIMT with visfatin (p = 0.005), BASDAI (p < 0.001), and BASFI (p < 0.001). There was a positive relationship between visfatin with BASDAI (p < 0.001), and BASFI (p < 0.001).
CONCLUSION
Visfatin levels are increased and associated with impaired FMD and increased cIMT in patients with AS. Increased visfatin levels may be associated with subclinical atherosclerosis in AS.
背景/目的：强直性脊柱炎（AS）患者可在早年发生动脉粥样硬化性心脏病。血流介导的扩张（FMD）和颈动脉内膜中层厚度（cIMT）值是早期发现 AS 患者亚临床动脉粥样硬化的可靠标志物。我们旨在研究脂肪因子水平与 AS 患者亚临床动脉粥样硬化和内皮功能障碍的间接标志物之间的关系。
材料和方法
本研究纳入了 42 例 AS 患者和 42 名年龄、性别和体重指数（BMI）匹配的对照组。采用适当的方法测量脂肪因子水平、FMD 和 cIMT。
结果
AS 患者的脂肪因子水平明显高于对照组（p<0.001）。AS 患者的 FMD 值明显较低（p=0.007），而 cIMT 明显高于对照组（p=0.003）。FMD 与脂肪因子水平呈负相关（p=0.004），与 BASDAI（p=0.010）和 BASFI（p=0.007）呈负相关。cIMT 与脂肪因子（p=0.005）、BASDAI（p<0.001）和 BASFI（p<0.001）呈正相关。脂肪因子与 BASDAI（p<0.001）和 BASFI（p<0.001）呈正相关。
结论
AS 患者的脂肪因子水平升高，并与 FMD 受损和 cIMT 增加有关。升高的脂肪因子水平可能与 AS 中的亚临床动脉粥样硬化有关。
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