Department of Cardiology, Fujian Provincial Clinical College, Fujian Medical University, Fuzhou, 350001, Fujian, China.
Department of Cardiology, Hainan West Central Hospital, Danzhou, 571700, Hainan, China.
BMC Cardiovasc Disord. 2020 Jun 5;20(1):271. doi: 10.1186/s12872-020-01549-3.
Visfatin is an adipokine that related with the inflammation in atherosclerosis and the destabilization of atherosclerotic plaque. The aim of this study was to observe the relationship between visfatin and major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients.
We enrolled a total of 238 patients (183 AMI and 55 control) who underwent coronary angiography. Patients with AMI were followed for an average of 19.3 months and 159 patients were finally included in the study.
It was observed patients with AMI had higher serum visfatin levels than controls. The total incidence of MACEs was 11.32% (18/159) in AMI patients. After calculation of the Youden index, the best cut-off value of visfatin on the curve of receiver-operating characteristic was 8.799 ng/mL for predicting the occurrence of MACEs. The occurrence of MACEs was elevated in high-visfatin group (≥8.799 ng/mL) compared with low-visfatin group (≤8.799 ng/mL). The time to MACEs was correlated with visfatin (HR = 1.235, 95%CI 1.051-1.451, P = 0.01) and high-visfatin group had an earlier time to MACEs and a shorter time of cumulative survival.
Increased serum visfatin levels were observed in AMI patients, and correlated with an earlier onset and higher incidence of MACEs.
内脂素是一种与动脉粥样硬化炎症和动脉粥样硬化斑块不稳定有关的脂肪因子。本研究旨在观察内脂素与急性心肌梗死（AMI）患者主要不良心血管事件（MACEs）的关系。
我们共纳入了 238 名接受冠状动脉造影的患者（183 名 AMI 和 55 名对照）。AMI 患者的平均随访时间为 19.3 个月，最终有 159 名患者纳入研究。
AMI 患者血清内脂素水平高于对照组。AMI 患者的总 MACEs发生率为 11.32%（18/159）。计算 Youden 指数后，受试者工作特征曲线下内脂素的最佳截断值为 8.799ng/ml，用于预测 MACEs 的发生。高内脂素组（≥8.799ng/ml）MACEs 的发生率高于低内脂素组（≤8.799ng/ml）。MACEs 的发生时间与内脂素相关（HR=1.235，95%CI 1.051-1.451，P=0.01），高内脂素组发生 MACEs 的时间更早，累积生存率更短。
AMI 患者血清内脂素水平升高，与 MACEs 的早期发生和更高的发生率相关。
