Li Rui, Chen Zhimin, Dai Zhifei, Yu Yingjie
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Cancer Biol Med. 2021 Mar 23;18(2):388-400. doi: 10.20892/j.issn.2095-3941.2020.0328.
Drug resistance is considered the most important reason for the clinical failure of cancer chemotherapy. Circumventing drug resistance and improving the efficacy of anticancer agents remains a major challenge. Over the past several decades, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have attracted substantial attention for their efficacy in cancer treatment, and have been combined with chemotherapy to overcome drug resistance. However, simultaneously delivering sensitizers and chemotherapy drugs to same tumor cell remains challenging, thus greatly limiting this combinational therapy. The rapid development of nanotechnology provides a new approach to solve this problem. Nano-based drug delivery systems can not only improve the targeted delivery of agents but also co-deliver multiple drug components in single nanoparticles to achieve optimal synergistic effects. In this review, we briefly summarize the mechanisms of drug resistance, discuss the advantages and disadvantages of PDT and SDT in reversing drug resistance, and describe state-of-the-art research using nano-mediated PDT and SDT to solve these refractory problems. This review also highlights the clinical translational potential for this combinational therapy.
耐药性被认为是癌症化疗临床失败的最重要原因。规避耐药性并提高抗癌药物的疗效仍然是一项重大挑战。在过去几十年中，光动力疗法（PDT）和声动力疗法（SDT）因其在癌症治疗中的疗效而备受关注，并已与化疗相结合以克服耐药性。然而，将敏化剂和化疗药物同时递送至同一肿瘤细胞仍然具有挑战性，从而极大地限制了这种联合疗法。纳米技术的快速发展为解决这一问题提供了新方法。基于纳米的药物递送系统不仅可以改善药物的靶向递送，还可以在单个纳米颗粒中共递送多种药物成分以实现最佳协同效应。在本综述中，我们简要总结了耐药机制，讨论了PDT和SDT在逆转耐药性方面的优缺点，并描述了使用纳米介导的PDT和SDT解决这些难治性问题的最新研究。本综述还强调了这种联合疗法的临床转化潜力。
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