Wang Yushu, Khan Shahin Shah, Ullah Irfan, Rady Ahmed, Aldahmash Badr, Yu Yingjie, Liu Luo, Zhu Xiulong
The People's Hospital of Gaozhou, National Drug Clinical Trial Institution Gaozhou City 525200 China
College of Life Science and Technology, Beijing University of Chemical Technology No. 15 East Road of North Third Ring Road Beijing 100029 China
RSC Adv. 2025 Feb 4;15(5):3439-3447. doi: 10.1039/d4ra06594h. eCollection 2025 Jan 29.
Bacterial infections, particularly those involving biofilms, pose significant treatment challenges due to their resistance to traditional antibiotics. Herein, this research explores the integration of selenium-tellurium nanoparticles (SeTe NP) and zinc oxide (ZnO) NP to create hybrid NP with dual photodynamic and photothermal properties. The synthesized SeTe-ZnO NP demonstrated significant efficacy against both Gram-positive (), () and Gram-negative (), () bacteria, effectively disrupting biofilm formation and promoting wound healing. studies further confirmed the biocompatibility and superior wound healing capabilities of SeTe-ZnO NP, highlighting their potential as a versatile and effective treatment for bacterial infections and wound care.
细菌感染,尤其是那些涉及生物膜的感染,由于其对传统抗生素具有抗性,给治疗带来了重大挑战。在此,本研究探索了硒化碲纳米颗粒(SeTe NP)与氧化锌(ZnO)纳米颗粒的整合,以制备具有光动力和光热双重特性的混合纳米颗粒。合成的SeTe-ZnO纳米颗粒对革兰氏阳性菌( )、( )和革兰氏阴性菌( )、( )均显示出显著疗效,有效破坏生物膜形成并促进伤口愈合。 研究进一步证实了SeTe-ZnO纳米颗粒的生物相容性和卓越的伤口愈合能力,突出了它们作为细菌感染和伤口护理的通用有效治疗方法的潜力。