State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Institute of Marine Biomedicine/Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic, Shenzhen 518055, China.
J Org Chem. 2021 Apr 2;86(7):5265-5273. doi: 10.1021/acs.joc.1c00156. Epub 2021 Mar 23.
The synthesis of two kinds of five-membered organosulfur heterocycles (i.e., 1,4,2-oxathiazoles and 1,3,4-thiadiazoles) from α-enolic dithioesters with active 1,3-dipoles (nitrile oxides and nitrilimines) generated in situ was achieved under mild reaction conditions. This transformation further expands the synthetic application of α-enolic dithioesters as the sulfur-containing building blocks.
两种五元含硫杂环化合物（1,4,2-氧硫杂环戊烷和 1,3,4-噻二唑）的合成是通过α-烯醇二硫酯与原位生成的活性 1,3-双烯（腈氧化物和亚胺）反应来实现的，反应条件温和。这一转化进一步扩展了α-烯醇二硫酯作为含硫砌块的合成应用。
