Bakhshaee Mehdi, Moradi Susan, Mohebi Masoud, Ghayour-Mobarhan Majid, Sharifan Payam, Yousefi Razieh, Rezaei Alireza, Rajati Mohsen
Sinus and Surgical Endoscopic Research Center, Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Otolaryngol Head Neck Surg. 2022 Jan;166(1):146-150. doi: 10.1177/01945998211000395. Epub 2021 Mar 23.
Ménière's disease (MD) is a well-known inner ear disease; however, the etiopathogenesis is unknown. Several factors may be involved. Meanwhile, vitamin D is reported to have an important role in inner ear physiology. The aim of this study is to evaluate the relation between vitamin D deficiency and MD.
This matched case-control study compared serum vitamin D levels between patients with definite MD and those without it.
The study was done between August 2018 and December 2019 at Ghaem University Hospital in Mashhad, Iran.
Twenty-eight patients with definite MD were matched with a group of 84 healthy individuals, regarding age, sex, body mass index, and occupation (indoor vs outdoor). The serum level of vitamin D (25-hydroxyvitamin D3) was measured in both groups.
The mean ± SD vitamin D level was 18.9 ± 9.7 ng/mL in the case group and 25.2 ± 13.7 ng/mL in the control group ( = .027). There was a significant difference between the case and control groups according to the results of the conditional logistic regression model ( = .03; adjusted odds ratio, 0.96). In the MD group, 17 (60.7%) patients were vitamin D deficient, 6 (21.4%) insufficient, and only 5 (17.9%) sufficient.
The results of this study show that serum vitamin D level in MD is significantly lower than that of the control group. However, the role of vitamin D supplementation in the management of MD needs further study.
梅尼埃病（MD）是一种广为人知的内耳疾病；然而，其病因发病机制尚不清楚。可能涉及多种因素。同时，据报道维生素D在内耳生理中起重要作用。本研究的目的是评估维生素D缺乏与MD之间的关系。
这项匹配病例对照研究比较了确诊为MD的患者与未患MD的患者的血清维生素D水平。
该研究于2018年8月至2019年12月在伊朗马什哈德的加姆大学医院进行。
28例确诊为MD的患者与一组84名健康个体在年龄、性别、体重指数和职业（室内与室外）方面进行匹配。两组均测量血清维生素D（25-羟基维生素D3）水平。
病例组维生素D水平的均值±标准差为18.9±9.7 ng/mL，对照组为25.2±13.7 ng/mL（P = .027）。根据条件逻辑回归模型的结果，病例组和对照组之间存在显著差异（P = .03；调整后的优势比为0.96）。在MD组中，17例（60.7%）患者维生素D缺乏，6例（21.4%）不足，只有5例（17.9%）充足。
本研究结果表明，MD患者的血清维生素D水平显著低于对照组。然而，补充维生素D在MD治疗中的作用需要进一步研究。
4级。
