Fundación IMSS, A.C., Paseo de la Reforma 476, Mz Pte. Colonia Juárez, Alcaldía Cuauhtémoc, 06600, Mexico City, Mexico.
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY, 10461, USA.
Curr Oncol Rep. 2021 Mar 23;23(5):56. doi: 10.1007/s11912-021-01043-9.
Acute leukemias represent a tremendous threat to public health around the globe and the main cause of death due to disease in scholar age children from developing nations. Here, we review their current status in Mexico, as a paradigm of study, and the major challenges to control systemic diseases like childhood cancer.
A unique molecular epidemiology, late/low precision diagnosis, limited access to treatment, toxicity associated with therapy, continuous exposure to environmental risk factors, and the high frequency of early relapses are some of the factors cooperating to low rates of survival in low-to-medium-income countries. Deliberative dialogues and exhaustive programs have emerged as promising means of advancing evidence-informed policy, by providing a structured forum for key stakeholders to integrate scientific and pragmatic knowledge about complex health concerns. A system-wide strategy based on the comprehensive leukemia identity is essential for a meaningful decline in early childhood mortality.
急性白血病对全球公共健康构成巨大威胁，也是发展中国家学龄儿童因病死亡的主要原因。在此，我们以墨西哥为范例，综述其现状，以及在控制儿童癌症等系统性疾病方面所面临的主要挑战。
独特的分子流行病学、晚期/低精度诊断、治疗机会有限、治疗相关毒性、持续暴露于环境风险因素，以及早期复发率高，这些因素共同导致中低收入国家的生存率较低。深思熟虑的对话和详尽的方案已成为推进循证政策的有希望的手段，为利益攸关方提供了一个结构化的论坛，以整合关于复杂健康问题的科学和务实知识。基于全面的白血病特征的系统策略对于降低儿童早期死亡率至关重要。
