Altay D U, Korkmaz M, Ergun S, Korkmaz H, Noyan T
Department of Nutrition and Dietetics, Ordu Unıversıty, Ordu, Turkey.
Eur Rev Med Pharmacol Sci. 2021 Mar;25(5):2252-2259. doi: 10.26355/eurrev_202103_25257.
Recurrent Aphthous Stomatitis (RAS) is the most common inflammatory condition of the oral mucosa characterised by recurrent onset of single or multiple painful ulcers mainly affecting the nonkeratinized oral mucosa. RAS mostly occurs in healthy individuals with no associated systemic diseases. Irisin is a newly identified adipomyokine and research has revealed that it has anti-inflammatory effects. The aim of this study was to investigate the significance of salivary irisin levels in patients with recurrent apthous stomatitis (RAS).
In this investigation, 80 individuals were evaluated. The patient group included 30 patients diagnosed with RAS and each control group consisted of 25 smoker and non-smoker healthy individuals. Saliva samples were collected and salivary irisin, interleukin-2 (IL-2) and interferon-ɣ (IF-ɣ) levels were determined using enzyme-linked immunosorbent assay (ELISA).
IL-2 and IF-ɣ levels in RAS patients were significantly higher than control smoker and non-smoker groups (p=0.0001, p=0.0001, respectively). Irisin level was higher in RAS patients than smoker controls and non-smoker controls. The level of irisin was found as sensitive and specific as IL-2 and more sensitive and specific than IF-ɣ. The salivary levels of pro-inflammatory cytokines IL-2 and IF-ɣ and irisin were higher in RAS group compared to controls.
This is the first report evaluating the irisin an adipo-myokine as an inflammatory biomarker in RAS.
复发性阿弗他口炎（RAS）是口腔黏膜最常见的炎症性疾病，其特征为单个或多个疼痛性溃疡反复发作，主要影响非角化口腔黏膜。RAS大多发生在无相关全身性疾病的健康个体中。鸢尾素是一种新发现的脂肪肌动蛋白，研究表明它具有抗炎作用。本研究的目的是探讨复发性阿弗他口炎（RAS）患者唾液中鸢尾素水平的意义。
在本调查中，对80名个体进行了评估。患者组包括30名诊断为RAS的患者，每个对照组由25名吸烟和不吸烟的健康个体组成。收集唾液样本，采用酶联免疫吸附测定（ELISA）法测定唾液中鸢尾素、白细胞介素-2（IL-2）和干扰素-γ（IF-γ）水平。
RAS患者的IL-2和IF-γ水平显著高于吸烟和不吸烟的对照组（分别为p = 0.0001，p = 0.0001）。RAS患者的鸢尾素水平高于吸烟对照组和不吸烟对照组。发现鸢尾素水平与IL-2一样敏感和特异，且比IF-γ更敏感和特异。与对照组相比，RAS组促炎细胞因子IL-2和IF-γ以及鸢尾素的唾液水平更高。
这是首篇评估鸢尾素这种脂肪肌动蛋白作为RAS炎症生物标志物的报告。
