Elamrousy Walid A, Mortada Ahmed, Shoukheba Malak
Department of Periodontology, Faculty of Dentistry, Kafrelsheikh University, Kafr Elsheikh, Egypt.
Department of Periodontology, Faculty of Dentistry, Assiut University, Assiut, Egypt.
J Int Soc Prev Community Dent. 2021 Sep 21;11(5):574-581. doi: 10.4103/jispcd.JISPCD_172_21. eCollection 2021 Sep-Oct.
The aim of this article is to evaluate the topical effect of camel whey protein (CWP) on the healing of recurrent aphthous stomatitis (RAS) and the serum levels of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α.
Forty patients with minor RAS were randomly assigned into control and study groups. The control group applied placebo methylcellulose gel topically over the aphthous ulcer, whereas the study group used CWP dissolved in methylcellulose gel topically over the aphthous ulcer. Healing period, pain scale, and serum inflammatory biomarkers were evaluated before and after gel application. Collected data were analyzed statistically using the paired -test or independent sample -test.
Ulcer healing period, pain scale, and immunological biomarkers were statistically improved in both groups with significant shortening of the ulcer duration and significant regulation of immunological values related to the study group.
Topical CWP gel is potentially effective in the treatment of RAS.
本文旨在评估骆驼乳清蛋白（CWP）对复发性阿弗他口炎（RAS）愈合的局部作用以及白细胞介素（IL）-1、IL-6和肿瘤坏死因子（TNF）-α的血清水平。
40例轻度RAS患者被随机分为对照组和研究组。对照组在阿弗他溃疡局部应用安慰剂甲基纤维素凝胶，而研究组使用溶解于甲基纤维素凝胶中的CWP在阿弗他溃疡局部应用。在凝胶应用前后评估愈合期、疼痛量表和血清炎症生物标志物。使用配对t检验或独立样本t检验对收集的数据进行统计学分析。
两组的溃疡愈合期、疼痛量表和免疫生物标志物均有统计学改善，溃疡持续时间显著缩短，与研究组相关的免疫值得到显著调节。
局部应用CWP凝胶对RAS的治疗可能有效。
