Ozturk F, Barman H A, Asoğlu R, Atici A
Cardiology Department, Yuzuncuyil University Faculty of Medicine, Van, Turkey.
Eur Rev Med Pharmacol Sci. 2021 Mar;25(5):2291-2298. doi: 10.26355/eurrev_202103_25261.
Epicardial fat thickness (EFT) and chlamydia infection are independent cardiovascular risk factors in coronary artery disease (CAD). We aimed to evaluate the effect of coexistence of EFT and chlamydia infection on the presence and severity of CAD in patients with stable angina pectoris (SAP).
The study included 208 patients with SAP, divided into a CAD group (n=112) and a control group (n=96). The presence of Chlamydia pneumoniae-IgG (CP-IgG), EFT, and left ventricular ejection fraction (LVEF) were compared between groups.
CP-IgG, LVEF, and EFT were found to be independent predictors of CAD (CP-IgG, OR=1.559, p=0.021; LVEF, OR=0.798, p<0.001; EFT, OR=3.175, p=0.026). Moreover, a statistically significant interaction was detected between CP-IgG and EFT for predicting the presence of CAD (p<0.001). A good positive correlation was found between EFT and Gensini score (r=0.684, p<0.001).
We found that there was an interaction between CP-Ig and EFT for CAD development. This finding suggests that the interaction of CP-IgG and EFT plays a prominent role in the inflammatory process.
心外膜脂肪厚度（EFT）和衣原体感染是冠状动脉疾病（CAD）中独立的心血管危险因素。我们旨在评估EFT与衣原体感染并存对稳定型心绞痛（SAP）患者CAD的存在及严重程度的影响。
该研究纳入208例SAP患者，分为CAD组（n = 112）和对照组（n = 96）。比较两组间肺炎衣原体IgG（CP-IgG）、EFT及左心室射血分数（LVEF）的情况。
发现CP-IgG、LVEF和EFT是CAD的独立预测因素（CP-IgG，OR = 1.559，p = 0.021；LVEF，OR = 0.798，p < 0.001；EFT，OR = 3.175，p = 0.026）。此外，在预测CAD的存在方面，检测到CP-IgG与EFT之间存在统计学上的显著交互作用（p < 0.001）。EFT与Gensini评分之间存在良好的正相关（r = 0.684，p < 0.001）。
我们发现CP-Ig与EFT在CAD发生过程中存在交互作用。这一发现表明CP-IgG与EFT的相互作用在炎症过程中起重要作用。
