血清脂肪因子与急性心肌梗死和稳定性心绞痛患者心外膜脂肪厚度及冠状动脉病变严重程度的相关性。
Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients.
机构信息
Department of Cardiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Department of Physiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
出版信息
Med Princ Pract. 2021;30(1):52-61. doi: 10.1159/000508834. Epub 2020 May 21.
OBJECTIVE
Adipolin/C1q/TNF-related protein-12 is a family of CTRPs highly expressed in adipose tissue with glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases, such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters.
SUBJECT AND METHODS
A total of 90 patients who were candidates for angiography were included in the study and divided into 3 groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as a control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.
RESULTS
Serum adipolin levels were significantly decreased in patients with AMI compared with the SAP and control groups (p < 0.001 for both). In addition, there was a negative association between serum levels of adipolin and epicardial fat thickness (EFT) and Gensini score in CAD patients. The results of multivariate linear regression analysis revealed that EFT values were independently associated with serum adipolin levels.
CONCLUSION
The current study showed an independent association of adipolin with EFT for the first time in patients with AMI. Decreased adipolin levels in patients with AMI may be involved in the process of atherosclerosis, which requires further study.
目的
脂肪因子/C1q/TNF 相关蛋白-12 是一种在脂肪组织中高度表达的 CTRP 家族，具有降低血糖和抗炎作用。各种危险因素被认为与心血管疾病的发生有关，如抗炎因子减少或炎症因子增加。本研究旨在探讨脂肪因子与人体测量学、血管造影、超声心动图和生化参数的相关性。
方法
本研究共纳入 90 名拟行血管造影的患者，并将其分为 3 组：30 名急性心肌梗死（AMI）患者、30 名稳定型心绞痛（SAP）患者和 30 名有胸痛但血管造影正常的对照组。所有受试者均测量人体测量学、血管造影、超声心动图和生化参数。
结果
与 SAP 组和对照组相比，AMI 患者的血清脂肪因子水平显著降低（均 p<0.001）。此外，在 CAD 患者中，血清脂肪因子水平与心外膜脂肪厚度（EFT）和 Gensini 评分呈负相关。多元线性回归分析结果表明，EFT 值与血清脂肪因子水平独立相关。
结论
本研究首次显示 AMI 患者的血清脂肪因子水平与 EFT 独立相关。AMI 患者脂肪因子水平降低可能参与了动脉粥样硬化的发生过程，这需要进一步研究。
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