miRNAs/lncRNAs 与核因子-κB（NF-κB）在人类疾病中的相互作用。
The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders.
机构信息
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Biomed Pharmacother. 2021 Jun;138:111519. doi: 10.1016/j.biopha.2021.111519. Epub 2021 Mar 20.
Nuclear factor-κB (NF-κB) represents a group of inducible transcription factors (TFs) regulating the expression of a great variety of genes implicated in diverse processes, particularly modulation of immune system responses. This TF has functional interactions with non-coding RNAs, constructing a complicated network through which NF-κB, miRNAs, and lncRNAs coordinately regulate gene expression at different facets. This type of interaction is involved in the pathophysiology of several human disorders including both neoplastic disorders and non-neoplastic conditions. MALAT1 and NKILA are among lncRNAs whose interactions with NF-κB have been vastly assessed in different conditions including cancer and inflammatory conditions. In addition, miR-146a/b has functional interactions with this TF in different contexts. Although miRNAs have mutual interactions with NF-κB, the regulatory role of miRNAs on this TF has been more clarified. The aim of the current review is to explore the function of NF-κB-related miRNAs and lncRNAs in these two types of human disorders.
核因子-κB（NF-κB）是一组诱导型转录因子（TFs），可调节多种基因的表达，这些基因参与多种过程，特别是免疫系统反应的调节。该 TF 与非编码 RNA 具有功能相互作用，通过这种相互作用构建了一个复杂的网络，其中 NF-κB、miRNAs 和 lncRNAs 可在不同方面协调基因表达。这种相互作用涉及多种人类疾病的病理生理学，包括肿瘤性疾病和非肿瘤性疾病。MALAT1 和 NKILA 是 lncRNAs 中的两种，其与 NF-κB 的相互作用已在癌症和炎症等不同情况下得到广泛评估。此外，miR-146a/b 在不同环境中与该 TF 具有功能相互作用。尽管 miRNAs 与 NF-κB 相互作用，但 miRNAs 对该 TF 的调节作用已更加明确。本综述的目的是探讨 NF-κB 相关 miRNAs 和 lncRNAs 在这两种人类疾病中的功能。
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