Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2021 Jun;138:111519. doi: 10.1016/j.biopha.2021.111519. Epub 2021 Mar 20.
Nuclear factor-κB (NF-κB) represents a group of inducible transcription factors (TFs) regulating the expression of a great variety of genes implicated in diverse processes, particularly modulation of immune system responses. This TF has functional interactions with non-coding RNAs, constructing a complicated network through which NF-κB, miRNAs, and lncRNAs coordinately regulate gene expression at different facets. This type of interaction is involved in the pathophysiology of several human disorders including both neoplastic disorders and non-neoplastic conditions. MALAT1 and NKILA are among lncRNAs whose interactions with NF-κB have been vastly assessed in different conditions including cancer and inflammatory conditions. In addition, miR-146a/b has functional interactions with this TF in different contexts. Although miRNAs have mutual interactions with NF-κB, the regulatory role of miRNAs on this TF has been more clarified. The aim of the current review is to explore the function of NF-κB-related miRNAs and lncRNAs in these two types of human disorders.
核因子-κB（NF-κB）是一组诱导型转录因子（TFs），可调节多种基因的表达，这些基因参与多种过程，特别是免疫系统反应的调节。该 TF 与非编码 RNA 具有功能相互作用，通过这种相互作用构建了一个复杂的网络，其中 NF-κB、miRNAs 和 lncRNAs 可在不同方面协调基因表达。这种相互作用涉及多种人类疾病的病理生理学，包括肿瘤性疾病和非肿瘤性疾病。MALAT1 和 NKILA 是 lncRNAs 中的两种，其与 NF-κB 的相互作用已在癌症和炎症等不同情况下得到广泛评估。此外，miR-146a/b 在不同环境中与该 TF 具有功能相互作用。尽管 miRNAs 与 NF-κB 相互作用，但 miRNAs 对该 TF 的调节作用已更加明确。本综述的目的是探讨 NF-κB 相关 miRNAs 和 lncRNAs 在这两种人类疾病中的功能。
