Li Mengfeng, Guan Hongyu
Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, China.
Adv Exp Med Biol. 2016;927:317-36. doi: 10.1007/978-981-10-1498-7_12.
As transcription factors that regulate expression of a variety of genes essential for diverse physiological and pathological processes, nuclear factor kappa B (NF-κB) family molecules play important roles in the development and progression of malignant tumor, and constitutive activation of NF-κB has been evidenced in various types of tumor tissues. Underlying its pathologic role, deregulated expression and/or transactivating activity of NF-κB usually involves multiple layers of molecular mechanisms. Noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are known to modulate expression and biological functions of regulatory proteins in a variety of cancer contexts. In this chapter, the regulatory role of miRNAs and lncRNAs in NF-κB signaling in malignant diseases will be discussed.
作为调节多种生理和病理过程所必需的各种基因表达的转录因子，核因子κB（NF-κB）家族分子在恶性肿瘤的发生和发展中发挥重要作用，并且在各种类型的肿瘤组织中已证实NF-κB的组成性激活。在其病理作用的背后，NF-κB的表达失调和/或反式激活活性通常涉及多层分子机制。已知非编码RNA，包括微小RNA（miRNA）和长链非编码RNA（lncRNA），在多种癌症背景下调节调节蛋白的表达和生物学功能。在本章中，将讨论miRNA和lncRNA在恶性疾病中NF-κB信号传导中的调节作用。
