College of Information Engineering, Shenyang University, Shenyang 110044, China.
Math Biosci Eng. 2021 Feb 22;18(2):1864-1878. doi: 10.3934/mbe.2021097.
In this paper, a crystal image analysis method is presented to measure and predict crystal sizes, based on cooling crystallization of β-form L-glutamic acid (LGA) by using an in-situ non-invasive imaging system. The proposed method consists of image restoration, image segmentation, crystal size measurement, and size prediction. To cope with the effects of noise pollution, uneven illumination and movement blurring, the image processing method is conducted for segmenting crystal images captured from the stirring reactor. Thus, the crystal size distribution for crystal population is obtained by using a probability density function. In addition, a short-term prediction method is given for crystal sizes. An experimental study on the cooling crystallization process of β-form LGA is shown to demonstrate the effectiveness of the proposed method.
本文提出了一种基于原位非侵入成像系统的β-型 L-谷氨酸（LGA）冷却结晶的晶体图像分析方法，用于测量和预测晶体尺寸。该方法包括图像恢复、图像分割、晶体尺寸测量和尺寸预测。为了应对噪声污染、光照不均匀和运动模糊的影响，对从搅拌反应器中捕获的晶体图像进行了图像处理，以使用概率密度函数获得晶体群体的晶体尺寸分布。此外，还给出了一种短期预测晶体尺寸的方法。通过β-型 LGA 的冷却结晶过程的实验研究，验证了所提出方法的有效性。
