Department of Urology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing 210000, China.
Department of Urology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing 210000, China.
Reprod Toxicol. 2021 Apr;101:124-136. doi: 10.1016/j.reprotox.2021.03.004. Epub 2021 Mar 20.
The effect of post-adolescence bisphenol A (BPA) exposure on the reproductive system is not well-defined. We therefore performed this meta-analysis to elucidate the associations between post-adolescence BPA exposure and reproductive-related outcomes. A search was performed on the PubMed, EMBASE, and Web of science databases to identify relevant literature. The standardized mean differences (SMDs) and the 95 % confidence intervals (CIs) were measured by fixed-effects or random-effects models. Publication bias was assessed using funnel plots and Egger's regression test. A total of 40 studies were included in the final analysis. The results showed that post-adolescence BPA exposure was negatively associated with reproductive-related organ weighty (Testis weight: SMD: -0.61; 95 % Cl: -0.85, -0.36; epididymis weight; SMD: -0.43; 95 % Cl: -0.69, -0.17; seminal vesicles weight; SMD: -0.77; 95 % Cl: -1.05, -0.49) and sperm parameters (Sperm motility: SMD: -1.44; 95 % Cl: -1.95, -0.93; epididymal sperm concentration: SMD: -2.26; 95 % Cl: -2.79, -1.72; and abnormal sperm morphology: SMD: 2.41; 95 % Cl: 1.41, 2.86). Moreover, BPA exposure decreased the level of testosterone (T) and superoxide dismutase (SOD), but increased the ratio of serum estradiol (E2) to T. This systematic review demonstrates that post-adolescence exposure to BPA may adversely affect reproductive functions in male rodents.
青春期后双酚 A（BPA）暴露对生殖系统的影响尚不清楚。因此，我们进行了这项荟萃分析，以阐明青春期后 BPA 暴露与生殖相关结局之间的关系。在 PubMed、EMBASE 和 Web of Science 数据库中进行了检索，以确定相关文献。使用固定效应或随机效应模型测量标准化均数差（SMD）和 95%置信区间（CI）。使用漏斗图和 Egger 回归检验评估发表偏倚。共有 40 项研究纳入最终分析。结果表明，青春期后 BPA 暴露与生殖相关器官重量呈负相关（睾丸重量：SMD：-0.61；95%CI：-0.85，-0.36；附睾重量；SMD：-0.43；95%CI：-0.69，-0.17；精囊重量；SMD：-0.77；95%CI：-1.05，-0.49）和精子参数（精子活力：SMD：-1.44；95%CI：-1.95，-0.93；附睾精子浓度：SMD：-2.26；95%CI：-2.79，-1.72；和异常精子形态：SMD：2.41；95%CI：1.41，2.86）。此外，BPA 暴露降低了睾酮（T）和超氧化物歧化酶（SOD）的水平，但增加了血清雌二醇（E2）与 T 的比值。这项系统评价表明，青春期后 BPA 暴露可能对雄性啮齿动物的生殖功能产生不利影响。
