动物模型中邻苯二甲酸二丁酯暴露与生殖相关结局：来自啮齿动物研究的证据
Exposure to Dibutyl Phthalate and Reproductive-Related Outcomes in Animal Models: Evidence From Rodents Study.
作者信息
Wang Jiawei, Zhang Xi, Li Yang, Liu Yingqing, Tao Lingsong
机构信息
Department of Urology, The Second People's Hospital of Wuhu, Wuhu, China.
The State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Front Physiol. 2021 Dec 8;12:684532. doi: 10.3389/fphys.2021.684532. eCollection 2021.
Dibutyl phthalate (DBP) was an endocrine disruptor, which may lead to cancer and affects reproductive function when accumulated in the body. But the precise role of DBP in the reproductive system remained controversial. We employed the meta-analysis to explore the relationship between DBP and reproductive-related outcomes. We searched relevant literature in PubMed, EMBASE, and Web of Science databases. The standardized mean differences (SMDs) and their 95% CIs were measured by random-effects models. Funnel plots and Egger's regression test were applied to assess publication bias. Finally, 19 literatures were included in this research. The outcomes revealed that DBP was negatively correlated with reproductive organs weight (testis weight: SMD: -0.59; 95% Cl: -1.23, -0.23; seminal vesicles weight: SMD: -0.74; 95% Cl: -1.21, -0.27; prostate weight: SMD: -0.46; 95% Cl: -0.76, -0.16) and sperm parameters (sperm morphology: SMD: 1.29; 95% Cl: 0.63, 1.94; sperm count: SMD: -1.81; 95% Cl: -2.39, -1.23; sperm motility: SMD: -1.92; 95% Cl: -2.62, -1.23). Our research demonstrated that DBP may be negatively associated with reproductive-related indicators, especially at Gestation exposure period and middle dose (100-500 mg/kg/day).
邻苯二甲酸二丁酯（DBP）是一种内分泌干扰物，在体内蓄积时可能致癌并影响生殖功能。但DBP在生殖系统中的具体作用仍存在争议。我们采用荟萃分析来探讨DBP与生殖相关结局之间的关系。我们在PubMed、EMBASE和Web of Science数据库中检索了相关文献。采用随机效应模型测量标准化均值差（SMD）及其95%置信区间（CI）。应用漏斗图和Egger回归检验评估发表偏倚。最终，本研究纳入了19篇文献。结果显示，DBP与生殖器官重量（睾丸重量：SMD：-0.59；95%CI：-1.23，-0.23；精囊重量：SMD：-0.74；95%CI：-1.21，-0.27；前列腺重量：SMD：-0.46；95%CI：-0.76，-0.16）和精子参数（精子形态：SMD：1.29；95%CI：0.63，1.94；精子计数：SMD：-1.81；95%CI：-2.39，-1.23；精子活力：SMD：-1.92；95%CI：-2.62，-1.23）呈负相关。我们的研究表明，DBP可能与生殖相关指标呈负相关，尤其是在孕期暴露期和中等剂量（100 - 500 mg/kg/天）时。
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