Vesterqvist O, Schött U, Berséus O, Axelsson K, Gréen K
Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.
Scand J Clin Lab Invest. 1988 May;48(3):233-9. doi: 10.3109/00365518809167489.
The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.
通过测量八名接受全髋关节置换术患者尿液中的主要代谢产物，对血栓素和前列环素的体内生成情况进行了研究。采用基于气相色谱 - 质谱联用的特定方法来测量2,3 - 二去甲 - 血栓素B2（2,3 - dinor - TxB2）和2,3 - 二去甲 - 6 - 酮 - 前列环素F1α（2,3 - dinor - 6 - keto - PGF1α）的尿排泄量。这些代谢产物的排泄量在术中及术后即刻增加了约10倍，术后4天仍高于术前。血栓素生成增加反映了血小板可能被激活，而前列环素增加可能是血管对诱导性血栓形成活动的防御机制的一部分。这些发现可能具有病理生理学意义。
