Culbreth Adam J, Moran Erin K, Kandala Sri, Westbrook Andrew, Barch Deanna M
Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Clin Psychol Sci. 2020 May 1;8(3):555-568. doi: 10.1177/2167702620901558. Epub 2020 Apr 22.
Recent research suggests that schizophrenia is associated with reduced effort allocation. We examined willingness to expend effort, neural correlates of effort allocation, and the relationship of effort to daily motivational experience in schizophrenia. We recruited 28 individuals with schizophrenia and 30 controls to perform an effort task during fMRI. Individuals with schizophrenia also completed an ecological momentary assessment (EMA) protocol. Individuals with schizophrenia with high negative symptoms were less willing to expend effort for rewards. Daily EMA assessments of motivation were positively associated with effort allocation at a trend-level. Individuals with schizophrenia and controls displayed similar increases in BOLD activation in frontal, cingulate, parietal, and insular regions during effort-based decision-making. However, negative symptoms were associated with reduced BOLD activation in bilateral ventral striatum. These results replicate previous reports of reduced effort allocation in schizophrenia patients with severe negative symptoms, and provide evidence for the role of ventral striatum in effort impairments.
近期研究表明，精神分裂症与努力分配减少有关。我们研究了精神分裂症患者付出努力的意愿、努力分配的神经关联以及努力与日常动机体验之间的关系。我们招募了28名精神分裂症患者和30名对照者，在功能磁共振成像（fMRI）期间执行一项努力任务。精神分裂症患者还完成了一项生态瞬时评估（EMA）方案。具有高阴性症状的精神分裂症患者为获得奖励而付出努力的意愿较低。日常EMA动机评估与努力分配在趋势水平上呈正相关。在基于努力的决策过程中，精神分裂症患者和对照者在额叶、扣带回、顶叶和岛叶区域的血氧水平依赖（BOLD）激活均有类似增加。然而，阴性症状与双侧腹侧纹状体的BOLD激活减少有关。这些结果重复了先前关于严重阴性症状的精神分裂症患者努力分配减少的报道，并为腹侧纹状体在努力受损中的作用提供了证据。
