Department of Veterans Affairs VISN 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA.
UCLA Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, Los Angeles, CA.
Schizophr Bull. 2018 Oct 17;44(6):1217-1226. doi: 10.1093/schbul/sbx156.
Effort-based decision-making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Research has shown associations between effort-based decision making and experiential negative symptoms; however, the associations are not consistent. The current study had two primary goals. First, we aimed to replicate previous findings of a deficit in effort-based decision making among individuals with schizophrenia on a test of cognitive effort. Second, in a large sample combined from the current and a previous study, we sought to examine the association between negative symptoms and effort by including the related construct of defeatist beliefs. The results replicated previous findings of impaired cognitive effort-based decision making in schizophrenia. Defeatist beliefs significantly moderated the association between negative symptoms and effort-based decision making such that there was a strong association between high negative symptoms and deficits in effort-based decision making, but only among participants with high levels of defeatist beliefs. Thus, our findings suggest the relationship between negative symptoms and effort performance may be understood by taking into account the role of defeatist beliefs, and finding that might explain discrepancies in previous studies.
基于努力的决策范式越来越多地被用于深入了解动机缺陷的本质。研究表明,基于努力的决策与体验性阴性症状之间存在关联;然而,这些关联并不一致。本研究有两个主要目标。首先,我们旨在复制先前在认知努力测试中发现的精神分裂症个体在基于努力的决策方面存在缺陷的发现。其次,在当前研究和先前研究的大样本中,我们通过纳入相关的失败信念结构,试图检验阴性症状与努力之间的关联。研究结果复制了精神分裂症患者认知努力基于努力的决策受损的先前发现。失败信念显著调节了阴性症状与基于努力的决策之间的关联,使得在高阴性症状和基于努力的决策缺陷之间存在强烈关联,但仅在高水平失败信念的参与者中存在。因此,我们的研究结果表明,考虑到失败信念的作用,可能可以理解阴性症状与努力表现之间的关系,这可能可以解释先前研究中的差异。