Morosowa L W, Klimm W, Maiwald H J
Stomatol DDR. 1977 Oct;27(10):659-64.
An experiment with 80 Wistar rats was performed to study, using cultural methods, the effect of locally and internally applied caries-preventive agents on the microbiological situation in the oral cavity and on the surface of the skin. Especially in case of combined internal and local application, fluoride-containing preparations exerted an inhibitory effect on the oral microflora that had been altered by a cariogenic diet and on the bacterial invasion of the skin. The influence of a locally applied mineral solution on bacterial growth was only insignificant.
用80只Wistar大鼠进行了一项实验，采用培养方法研究局部和全身应用防龋剂对口腔和皮肤表面微生物状况的影响。特别是在全身和局部联合应用的情况下，含氟制剂对因致龋饮食而改变的口腔微生物群以及皮肤的细菌入侵具有抑制作用。局部应用矿物质溶液对细菌生长的影响微不足道。
