餐后脂肪酸谱，而非心血管代谢风险标志物，可通过对有中度心血管疾病风险的成年人进行乳制品脂肪干预来调节：随机对照饱和脂肪替代乳制品总胆固醇研究（RESET）。
Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study.
机构信息
Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom.
Animal, Dairy, and Food Chain Sciences, University of Reading, Reading, United Kingdom.
出版信息
J Nutr. 2021 Jul 1;151(7):1755-1768. doi: 10.1093/jn/nxab050.
BACKGROUND
Chronic consumption of dairy products with an SFA-reduced, MUFA-enriched content was shown to impact favorably on brachial artery flow-mediated dilatation (FMD). However, their acute effect on postprandial cardiometabolic risk biomarkers requires investigation.
OBJECTIVE
The effects of sequential high-fat mixed meals rich in fatty acid (FA)-modified or conventional (control) dairy products on postprandial FMD (primary outcome) and systemic cardiometabolic biomarkers in adults with moderate cardiovascular risk (≥50% above the population mean) were compared.
METHODS
In a randomized crossover trial, 52 participants [mean ± SEM age: 53 ± 2 y; BMI (kg/m2) 25.9 ± 0.5] consumed a high-dairy-fat breakfast (0 min; ∼50 g total fat: modified: 25 g SFAs, 20 g MUFAs; control: 32 g SFAs, 12 g MUFAs) and lunch (330 min; ∼30 g total fat; modified: 15 g SFAs, 12 g MUFAs; control: 19 g SFAs, 7 g MUFAs). Blood samples were obtained before and until 480 min after breakfast, with FMD assessed at 0, 180, 300, and 420 min. Data were analyzed by linear mixed models.
RESULTS
Postprandial changes in cardiometabolic biomarkers were comparable between the different dairy meals, with the exception of a tendency for a 4% higher AUC for the %FMD response following the modified-dairy-fat meals (P = 0.075). Plasma total lipid FA analysis revealed that incremental AUC responses were 53% lower for total SFAs, 214% and 258% higher for total cis-MUFAs (predominantly cis-9 18:1), and trans-18:1, respectively, following the modified relative to the control dairy meals (all P < 0.0001).
CONCLUSIONS
In adults at moderate cardiovascular risk, acute consumption of sequential high-fat meals containing FA-modified dairy products had little impact on postprandial endothelial function or systemic cardiometabolic biomarkers, but a differential effect on the plasma total lipid FA profile, relative to conventional dairy fat meals.This trial was registered at clinicaltrials.gov as NCT02089035.
背景
慢性摄入 SFA 减少、MUFA 丰富的乳制品被证明对肱动脉血流介导的扩张（FMD）有积极影响。然而，它们对餐后心血管代谢风险生物标志物的急性影响仍需要研究。
目的
比较富含脂肪酸（FA）修饰或传统（对照）乳制品的序贯高脂肪混合餐对中等心血管风险（高于人群平均值的 50%以上）成年人的餐后 FMD（主要结局）和全身心血管代谢生物标志物的影响。
方法
在一项随机交叉试验中，52 名参与者[平均±SEM 年龄：53±2 岁；BMI（kg/m2）25.9±0.5]摄入高脂肪早餐（0 分钟；约 50g 总脂肪：修饰：25g SFA，20g MUFA；对照：32g SFA，12g MUFA）和午餐（330 分钟；约 30g 总脂肪；修饰：15g SFA，12g MUFA；对照：19g SFA，7g MUFA）。在早餐前和早餐后 480 分钟内采集血液样本，并在 0、180、300 和 420 分钟时评估 FMD。数据通过线性混合模型进行分析。
结果
不同乳制品餐之间的心血管代谢生物标志物的餐后变化相当，除了修饰乳制品餐后的%FMD 反应的 AUC 有增加 4%的趋势（P=0.075）。血浆总脂质 FA 分析显示，与对照乳制品餐相比，修饰乳制品餐的总 SFA 的增量 AUC 反应低 53%，总 cis-MUFA（主要为 cis-9 18:1）和反式-18:1 分别高 214%和 258%（均 P<0.0001）。
结论
在中等心血管风险的成年人中，急性摄入含有 FA 修饰乳制品的序贯高脂肪餐对餐后内皮功能或全身心血管代谢生物标志物几乎没有影响，但对血浆总脂质 FA 谱有差异影响，与传统乳制品脂肪餐相比。这项试验在 clinicaltrials.gov 注册为 NCT02089035。
Zotero 插件