Wilhelm K R, Schulz-Wendtland R
Nuklearmedizinische Abteilung der Universitäts-Strahlenklinik Heidelberg.
Strahlenther Onkol. 1988 May;164(5):270-7.
The irradiation of cervical lymphatics in case of oral and pharyngeal carcinomas as well as the irradiation of the operated area in case of laryngeal carcinomas leads to an exposition of the thyroid gland which may result in a dysfunction of this organ. An evaluation of our patients suffering from these tumors and treated during 1984 and 1985 showed a latent hypothyreosis in 46.7% of the patients treated only by cervical irradiation and in 20.7% of the cases treated by radiotherapy of the tumoral focus and additional irradiation of the cervical lymphatics (p less than 0.1). Clinical symptoms were scarcely evident in both groups. For struma prophylaxis, thyreosubstitution with L-thyroxine is recommended.
口腔癌和咽癌患者颈部淋巴管的照射以及喉癌患者手术区域的照射会导致甲状腺暴露，这可能会导致该器官功能障碍。对1984年至1985年期间接受治疗的这些肿瘤患者的评估显示，仅接受颈部照射的患者中有46.7%出现潜在甲状腺功能减退，而接受肿瘤灶放射治疗并额外照射颈部淋巴管的患者中有20.7%出现这种情况（p小于0.1）。两组患者的临床症状都不明显。为预防甲状腺疾病，建议用左旋甲状腺素进行甲状腺替代治疗。
