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[新型冠状病毒肺炎与自身免疫性疾病]

[COVID-19 AND AUTOIMMUNE DISEASES].

作者信息

Dotan Arad, Shoenfeld Yehuda

机构信息

MD MPH studies, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Harefuah. 2021 Feb;160(2):62-67.

Abstract

The immune system could be affected by a mixture of factors. It is customary to classify factors that affect the immune system into three main groups: hereditary, environmental and hormonal factors. When those factors deviate from their normal physiological effect, in the genetically pre-dispositioned, an autoimmune disease may erupt and a lymphoma may develop as a result. Viruses are a significant part of the environmental factors that affect the immune system. Recent evidence demonstrates the ability of the COVID-19 virus to induce hyper-stimulation of the immune system, thus leading to the formation of autoantibodies in patients. This effect of the COVID-19 virus is caused by two main courses of action: firstly, its ability to induce hyper-stimulation of the immune system; secondly, its molecular similarity to humans. Numerous records demonstrate the tendency of severely ill COVID-19 patients to develop multiple autoantibodies known to be found in common autoimmune diseases, such as antinuclear antibodies, antiphospholipid antibodies, and many more. Additionally, many case reports have been published on COVID-19 infected patients who developed autoimmune diseases. It is extremely important to recognize the autoimmune effects of the COVID-19 virus when dealing with the ongoing pandemic.

摘要

免疫系统可能会受到多种因素的影响。通常将影响免疫系统的因素分为三大类:遗传因素、环境因素和激素因素。当这些因素偏离其正常生理效应时,对于有遗传易感性的个体,可能会引发自身免疫性疾病,并可能导致淋巴瘤的发生。病毒是影响免疫系统的环境因素中的重要组成部分。最近的证据表明,新冠病毒能够诱导免疫系统的过度刺激,从而导致患者体内产生自身抗体。新冠病毒的这种效应主要由两个主要作用途径引起:其一,它诱导免疫系统过度刺激的能力;其二,它与人类的分子相似性。大量记录表明,重症新冠患者倾向于产生多种在常见自身免疫性疾病中发现的自身抗体,如抗核抗体、抗磷脂抗体等等。此外,已经发表了许多关于感染新冠病毒后患上自身免疫性疾病患者的病例报告。在应对当前的疫情时,认识到新冠病毒的自身免疫效应极其重要。

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