Diamond Matthew, Peniston Hector L., Sanghavi Devang K., Mahapatra Sidharth, Doerr Chaddie
Zucker School of Medicine at Hofstra/Northwell
FIU Herbert Wertheim College of Medicine
Acute respiratory distress syndrome (ARDS) is a life-threatening condition of seriously ill patients, characterized by poor oxygenation, pulmonary infiltrates, and acute onset. On a microscopic level, the disorder is associated with capillary endothelial injury and diffuse alveolar damage. ARDS is an acute disorder characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients usually have a PaO2/FiO2 ratio of less than 200. Once ARDS develops, patients usually have varying degrees of pulmonary artery vasoconstriction and may subsequently develop pulmonary hypertension. ARDS carries a high mortality, and few effective therapeutic modalities exist to combat this condition.[1][2]
急性呼吸窘迫综合征（ARDS）是一种危及重症患者生命的病症，其特征为氧合功能差、肺部浸润和急性起病。在微观层面，该病症与毛细血管内皮损伤和弥漫性肺泡损伤相关。ARDS是一种急性病症，其特征为双侧肺部浸润以及在无任何心源性肺水肿证据的情况下出现严重的进行性低氧血症。ARDS通过患者动脉血中的氧分压（PaO2）与吸入空气中的氧分数（FiO2）来定义。这些患者的PaO2/FiO2比值通常小于200。一旦ARDS发生，患者通常会出现不同程度的肺动脉血管收缩，随后可能发展为肺动脉高压。ARDS的死亡率很高，并且几乎没有有效的治疗方法来对抗这种病症。[1][2]
