Center of Research on Psychological and Somatic disorders (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, PO Box 90153, 5000, LE, Tilburg, The Netherlands.
Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, P. Debyeplein 1, 6200, MD, Maastricht, The Netherlands.
Support Care Cancer. 2021 Oct;29(10):5935-5943. doi: 10.1007/s00520-021-06104-0. Epub 2021 Mar 24.
Alcohol consumption can lead to worse prognosis and mortality among colorectal cancer (CRC) patients. We investigated alcohol consumption of CRC survivors up to 2 years post-diagnosis, and how sociodemographic, lifestyle, and clinical factors were associated longitudinally with these habits.
We pooled longitudinal data of 910 CRC survivors from the ongoing PROCORE and EnCoRe studies with data collected at diagnosis (baseline) and 3, 6, 12, and 24 months post-diagnosis. Both studies assessed alcohol consumption, including beer, wine, and liquor. Generalized estimated equation models were used to examine changes over time in alcohol consumption and multivariable longitudinal associations of sociodemographic, lifestyle, and clinical factors with alcohol consumption.
At baseline, participants were on average 67 years old, 332 (37%) were female, and alcohol was consumed by 79%. Most survivors (68-71%) drank less at all follow-ups. Beer, wine, and liquor were consumed by 51%, 58%, and 25% at baseline, respectively, and these declined over time. Males consumed more alcohol, and higher education, more physical activity, and not having a (permanent) stoma were associated with consuming more alcohol.
CRC survivors decreased their alcohol consumption in the 2 years post-diagnosis. Future studies should take the significant factors that were associated with alcohol post-diagnosis consumption into account, when they investigate CRC health outcomes or for identifying subgroups for interventions. Males with higher education, more physical activity, and no stoma should be reminded after diagnosis for reducing their alcohol consumption.
饮酒可导致结直肠癌（CRC）患者预后更差和死亡率更高。我们调查了CRC 幸存者在诊断后 2 年内的饮酒情况，以及社会人口统计学、生活方式和临床因素如何与这些习惯进行纵向关联。
我们汇集了正在进行的 PROCORE 和 EnCoRe 研究中 910 名 CRC 幸存者的纵向数据，这些数据是在诊断时（基线）以及诊断后 3、6、12 和 24 个月收集的。这两项研究都评估了包括啤酒、葡萄酒和白酒在内的饮酒情况。使用广义估计方程模型来检查饮酒习惯随时间的变化，以及社会人口统计学、生活方式和临床因素与饮酒习惯的多变量纵向关联。
基线时，参与者的平均年龄为 67 岁，332 名（37%）为女性，79%的人饮酒。大多数幸存者（68-71%）在所有随访中饮酒量都减少了。基线时分别有 51%、58%和 25%的人饮用啤酒、葡萄酒和白酒，这些比例随时间逐渐下降。男性饮酒量较多，而较高的教育程度、更多的体育活动以及没有（永久性）造口与饮酒量较多有关。
CRC 幸存者在诊断后 2 年内减少了饮酒量。未来的研究在调查 CRC 健康结果或确定干预的亚组时，应该考虑与诊断后饮酒消费相关的重要因素。应该提醒那些诊断后具有较高教育程度、更多体育活动和没有造口的男性减少饮酒量。
