Center of Research on Psychological disorders and Somatic diseases, Tilburg University, PO Box 90153, 5000 LE, Tilburg, The Netherlands.
Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
J Cancer Surviv. 2022 Oct;16(5):988-997. doi: 10.1007/s11764-021-01090-y. Epub 2021 Sep 16.
Alcohol consumption is a major risk factor for colorectal cancer (CRC). It is currently poorly understood, however, how alcohol and different alcoholic beverage types are related to psychosocial outcomes in CRC survivors.
We used data of N = 910 CRC survivors from the pooled EnCoRe and PROCORE cohorts and harmonized them into five time points: at diagnosis and 3, 6, 12, and 24 months post-diagnosis. Generalized estimated equation models were used to examine longitudinal associations of alcohol consumption, including consumption of beer, wine, and liquor, with anxiety, depression, and health-related quality of life (HRQoL), while correcting for sociodemographic, lifestyle, and clinical factors.
Survivors were on average 67 years and 37% was female. In the first 2 years post-diagnosis, survivors who consumed more alcoholic drinks/week reported lower anxiety and depressive symptoms and better HRQoL on all domains and symptom scales. This was the case for moderate and heavy amounts of alcohol and mostly for consuming beer and wine, but not for liquor. Associations were more often significant for men and for younger persons (< 67 years at baseline).
Generally, alcohol consumption was observed to be longitudinally related to less anxiety and depression and better HRQoL in CRC survivors.
Although alcohol consumption is generally unfavorable due to increased risk of carcinogenesis and worse prognosis after CRC, it seems to be associated with better psychosocial outcomes in the first 2 years after diagnosis and treatment. More research is needed to gain knowledge about reasons for drinking and causality.
饮酒是结直肠癌（CRC）的主要危险因素。然而，目前尚不清楚酒精和不同类型的酒精饮料如何与 CRC 幸存者的心理社会结局相关。
我们使用了来自 EnCoRe 和 PROCORE 两个队列的 910 名 CRC 幸存者的数据，并将其统一到五个时间点：诊断时以及诊断后 3、6、12 和 24 个月。使用广义估计方程模型来检查酒精消耗（包括啤酒、葡萄酒和白酒的消耗）与焦虑、抑郁和健康相关生活质量（HRQoL）的纵向关联，同时校正社会人口统计学、生活方式和临床因素。
幸存者的平均年龄为 67 岁，37%为女性。在诊断后的前 2 年内，每周饮酒量较高的幸存者报告焦虑和抑郁症状较轻，所有领域和症状量表的 HRQoL 更好。这种情况适用于中等和大量饮酒，主要是饮用啤酒和葡萄酒，但不适用于白酒。对于男性和年龄较小的人（<67 岁），相关性更常见且更显著。
总体而言，在 CRC 幸存者中，酒精消耗与较少的焦虑和抑郁以及更好的 HRQoL 呈纵向相关。
尽管由于致癌作用增加和 CRC 后预后恶化，饮酒通常不利，但在诊断和治疗后 2 年内，它似乎与更好的心理社会结局相关。需要进一步研究以了解饮酒的原因和因果关系。
