Breast Center, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Breast Cancer Res Treat. 2021 Jul;188(2):361-368. doi: 10.1007/s10549-021-06196-6. Epub 2021 Mar 24.
This study aimed to assess the efficacy of the combination of indocyanine green (ICG) and methylene blue (MB) dye in early breast cancer patients undergoing sentinel lymph node biopsy (SLNB).
Between January 2011 and December 2015, 1061 early breast cancer patients underwent SLNB were included. SLNB was performed for enrolled patients by injection of both ICG and MB. Detection rate, positivity, and number of sentinel lymph nodes (SLNs) by ICG and MB were analysed. Axillary recurrence and arm lymphedema at 5.6-year follow-up were reported.
The combination of ICG and MB resulted in a very high detection rate of 99.6%, the median number of sentinel lymph nodes was 3. A total of 374 histologically confirmed positive SLNs were detected in 237 patients, 96.6% of the positive patients and 94.1% of the positive nodes could be identified by the combination of ICG and MB. After a median follow-up of 5.6 (2-9.3) years, 0.64% of patients with negative SLNs had ipsilateral axillary recurrence, and the incidence of arm lymphedema was 2.1%.
Although the missing isotope control weakens the interpretation of the findings, the dual tracing modality of ICG and MB, without involvement of radioactive isotopes, was an effective method for SLNB in patients with early breast cancer.
ACTRN12612000109808. Registered on 23 January 2012.
本研究旨在评估吲哚菁绿（ICG）和亚甲蓝（MB）染料联合在接受前哨淋巴结活检（SLNB）的早期乳腺癌患者中的疗效。
纳入了 2011 年 1 月至 2015 年 12 月期间 1061 例早期乳腺癌患者。对纳入患者同时注射 ICG 和 MB 进行 SLNB。分析 ICG 和 MB 检测的检出率、阳性率和前哨淋巴结（SLN）数量。报告了 5.6 年随访时的腋窝复发和手臂淋巴水肿情况。
ICG 和 MB 的联合使用导致了非常高的检出率（99.6%），中位 SLN 数量为 3 个。在 237 例组织学确诊的阳性 SLN 患者中，共检测到 374 个阳性 SLN，阳性患者中有 96.6%，阳性节点中有 94.1%可以通过 ICG 和 MB 的联合使用识别。中位随访 5.6 年（2-9.3 年）后，阴性 SLN 的患者中有 0.64%发生同侧腋窝复发，手臂淋巴水肿的发生率为 2.1%。
尽管缺少同位素对照会削弱对结果的解释，但 ICG 和 MB 的双重示踪方式，不涉及放射性同位素，是一种对早期乳腺癌患者进行 SLNB 的有效方法。
ACTRN12612000109808。2012 年 1 月 23 日注册。
