Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
The Dingli Clinical College of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
BMC Surg. 2023 May 17;23(1):133. doi: 10.1186/s12893-023-02037-z.
Recent studies have shown that near-infrared (NIR) fluorescence imaging using Indocyanine green (ICG) may improve the efficiency of sentinel lymph node biopsy (SLNB). This study aimed to assess the effectiveness of the combination of ICG and methylene blue (MB) in breast cancer patients undergoing SLNB.
We evaluated ICG plus MB (ICG + MB) identification effectiveness with MB alone using retrospective analysis. From 2016 to 2020, we collected data on 300 eligible breast cancer patients who got SLNB treatment in our institution by ICG + MB or MB alone. By comparing the distribution of clinicopathological characteristics, the detection rate of sentinel lymph nodes (SLNs) and metastatic SLNs, as well as the total number of SLNs in the two groups, we were able to assess the imaging efficiency.
Fluorescence imaging allowed 131 out of 136 patients in the ICG + MB group to find SLNs. ICG + MB group and MB group had detection rates of 98.5% and 91.5% (P = 0.007, χ = 7.352), respectively. Besides, the ICG + MB approach was able to produce improved recognition outcomes. What's more, compared with the MB group, the ICG + MB group can identify more lymph nodes (LNs) (3.1 to 2.6, P = 0.000, t = 4.447). Additionally, in the ICG + MB group, ICG could identify more LNs than MB (3.1 vs 2.6, P = 0.004, t = 2.884).
ICG has high detection effectiveness for SLNs, and when paired with MB, the detection efficiency can be increased even further. Furthermore, the ICG + MB tracing mode does not involve radioisotopes, which has a lot of promise for clinical use and can take the place of conventional standard detection methods.
最近的研究表明，近红外（NIR）荧光成像结合吲哚菁绿（ICG）可能提高前哨淋巴结活检（SLNB）的效率。本研究旨在评估 ICG 联合亚甲蓝（MB）在接受 SLNB 的乳腺癌患者中的应用效果。
我们通过回顾性分析评估了 ICG 联合 MB（ICG+MB）与单独使用 MB 对 SLN 的识别效果。2016 年至 2020 年，我们收集了在我院接受 ICG+MB 或单独 MB 治疗的 300 例符合条件的乳腺癌患者的数据。通过比较两组患者的临床病理特征分布、前哨淋巴结（SLN）和转移性 SLN 的检出率以及 SLN 的总数，我们评估了成像效率。
荧光成像使 136 例 ICG+MB 组患者中的 131 例能够找到 SLN。ICG+MB 组和 MB 组的检出率分别为 98.5%和 91.5%（P=0.007，χ²=7.352）。此外，ICG+MB 方法能够产生更好的识别结果。与 MB 组相比，ICG+MB 组能够识别更多的淋巴结（LNs）（3.1 比 2.6，P=0.000，t=4.447）。此外，在 ICG+MB 组中，ICG 比 MB 能识别更多的 LNs（3.1 比 2.6，P=0.004，t=2.884）。
ICG 对 SLN 具有较高的检测效果，与 MB 联合使用时，检测效率可以进一步提高。此外，ICG+MB 示踪模式不涉及放射性同位素，具有很大的临床应用前景，可以替代传统的标准检测方法。
