Mayrovitz Harvey N, Somarriba Carmen, Weingrad Daniel N
Division of Physiology, Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Davie, Florida, USA.
Surgical Specialists of Miami, Aventura, Florida, USA.
Lymphat Res Biol. 2022 Feb;20(1):33-38. doi: 10.1089/lrb.2020.0137. Epub 2021 Mar 24.
Many methods can quantitatively assess limb lymphedema, but methods to assess breast edema/lymphedema are quite limited. Thus, there is a need for a convenient and accurate way to quantify and track changes in this condition. Herein, breast tissue dielectric constant (TDC) values that depend on tissue water were used to obtain reference TDC values and interbreast TDC ratios. TDC was measured in both breasts of 61 women who were about to undergo an ultrasound-guided diagnostic biopsy of a single mass (tumor) in 1 breast. Patient age and body mass index were (mean ± SD) 65.1 ± 11.6 (41-87 years) and 28.9 ± 5.1 (19.1-43.7 kg/m). TDC was measured at a standardized site (12 o'clock position) with the TDC probe placed with its outer edge at the periphery of the subareolar region. TDC values of healthy breasts versus tumor breasts showed tumor breasts 3% greater (30.4 ± 4.6 vs. 29.5 ± 4.6, = 0.02). Patients with benign tumors ( = 33) showed no difference between breasts (30.5 ± 4.4 vs. 30.8 ± 4.6 = 0.434) and had an interbreast TDC ratio (tumor breast/healthy breast) of 1.013 ± 0.077. Patients with malignant tumors ( = 28) had tumor breast values 5% greater (29.8 ± 4.8 vs. 28.4 ± 4.6, = 0.018) and an interbreast ratio of 1.056 ± 0.117. The overall interbreast ratio ( = 61) was 1.033 ± 0.099. Breast TDC values from nonedematous breasts provide the basis for calculating potential edematous/lymphedematous threshold values based on the measured means +2.5 standard deviation (SD). Accordingly, a TDC threshold value of 41 and an interbreast ratio of 1.28 were determined. These parameters have potential applicability for early detection in at-risk patients and those suspected of having breast edema/lymphedema.
许多方法可以定量评估肢体淋巴水肿，但评估乳腺水肿/淋巴水肿的方法却非常有限。因此，需要一种方便且准确的方法来量化和跟踪这种情况的变化。在此，利用依赖于组织水分的乳腺组织介电常数（TDC）值来获取参考TDC值和双侧乳腺TDC比值。对61名即将接受一侧乳腺单个肿块（肿瘤）超声引导下诊断性活检的女性双侧乳腺进行了TDC测量。患者年龄和体重指数分别为（均值±标准差）65.1±11.6（41 - 87岁）和28.9±5.1（19.1 - 43.7kg/m²）。在标准化部位（12点位置）测量TDC，将TDC探头的外缘置于乳晕下区域的周边。健康乳腺与肿瘤乳腺的TDC值显示，肿瘤乳腺高3%（30.4±4.6对29.5±4.6，P = 0.02）。良性肿瘤患者（n = 33）双侧乳腺无差异（30.5±4.4对30.8±4.6，P = 0.434），双侧乳腺TDC比值（肿瘤乳腺/健康乳腺）为1.013±0.077。恶性肿瘤患者（n = 28）肿瘤乳腺值高5%（29.8±4.8对28.4±4.6，P = 0.018），双侧乳腺比值为1.056±0.117。总体双侧乳腺比值（n = 61）为1.033±0.099。非水肿乳腺的乳腺TDC值为基于测量均值+2.5标准差（SD）计算潜在水肿/淋巴水肿阈值提供了依据。据此，确定了TDC阈值为41，双侧乳腺比值为1.28。这些参数在高危患者和疑似患有乳腺水肿/淋巴水肿患者的早期检测中具有潜在的适用性。
