Kilvington Alice, Barnaba Carlo, Rajasekaran Surender, Laurens Leimanis Mara L, Medina-Meza Ilce G
Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
Institute of Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
Food Chem. 2021 Aug 30;354:129529. doi: 10.1016/j.foodchem.2021.129529. Epub 2021 Mar 9.
Approximately two-thirds of US infants receive infant formula (IF) as a primary or sole nutritional source during the first six months of life. IF is available in a variety of commercial presentations; from a manufacturing standpoint, they can be categorized as powder- (PIF) or liquid- (LIF) based formulations. Thirty commercial IFs were analyzed in their oxidative and non-oxidative lipid profiles. We identified 7-ketocholesterol - a major end-product of cholesterol oxidation - as a potential biomarker of IF manufacturing. The statistical analysis allowed a re-classification of IF based on their metabolomic fingerprint, resulting in three groups assigned with low-to-high oxidative status. Finally, we modeled the dietary intake of cholesterol, sterols, and 7-ketocholesterol in the first year of life. The database provided in this study will be instrumental for scientists interested in infant nutrition, to establish bases for epidemiological studies aimed to find connections between nutrition and diet-associated diseases, such as sitosterolemia.
大约三分之二的美国婴儿在出生后的前六个月将婴儿配方奶粉（IF）作为主要或唯一的营养来源。IF有多种商业形式；从生产角度来看，它们可分为基于粉末的配方奶粉（PIF）或基于液体的配方奶粉（LIF）。对30种市售IF进行了氧化和非氧化脂质谱分析。我们确定了7-酮胆固醇——胆固醇氧化的主要终产物——作为IF生产的潜在生物标志物。统计分析允许根据IF的代谢组学指纹对其进行重新分类，从而产生了三组氧化状态从低到高的分类。最后，我们对生命第一年中胆固醇、甾醇和7-酮胆固醇的饮食摄入量进行了建模。本研究提供的数据库将有助于对婴儿营养感兴趣的科学家，为旨在寻找营养与饮食相关疾病（如植物甾醇血症）之间联系的流行病学研究奠定基础。
