Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, 1-4 Yamadaoka, Suita City, Osaka 565-0871, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, Japan.
Cell Rep. 2021 Mar 23;34(12):108885. doi: 10.1016/j.celrep.2021.108885.
Cooperative reactivation of hippocampal and prefrontal neurons is considered crucial for mnemonic processes. To directly record synaptic substances supporting the interregional interactions, we develop concurrent spike recordings of hippocampal neuronal ensembles and whole-cell patch-clamp recordings of medial prefrontal neurons in awake rats. We find that medial prefrontal neurons depolarize when hippocampal neurons synchronize. The depolarization in medial prefrontal neurons is larger when hippocampal place cells that encoded overlapping place fields and place cells that encoded a novel environment are synchronously reactivated. Our results suggest a functional circuit-synapse association that enables prefrontal neurons to read out specific memory traces from the hippocampus.
海马体和前额叶神经元的协同再激活被认为对记忆过程至关重要。为了直接记录支持区域间相互作用的突触物质，我们在清醒大鼠中同时记录海马体神经元集合的尖峰和内侧前额叶神经元的全细胞膜片钳记录。我们发现，当海马体神经元同步放电时，内侧前额叶神经元去极化。当编码重叠位置场的海马体位置细胞和编码新环境的位置细胞同步再激活时，内侧前额叶神经元的去极化更大。我们的结果表明，一种功能回路-突触关联使前额叶神经元能够从海马体中读取特定的记忆痕迹。
