Cardiology Division, Federal University of Santa Catarina, (UFSC), Florianópolis, SC, Brazil; Medical Sciences Post-graduate Program, Federal University of Santa Catarina, (UFSC), Florianópolis, SC, Brazil.
Medical Sciences Post-graduate Program, Federal University of Santa Catarina, (UFSC), Florianópolis, SC, Brazil; Neurology Division, Federal University of Santa Catarina, (UFSC), Florianópolis, SC, Brazil; Danish Epilepsy Centre, Dianalund, Denmark.
Seizure. 2021 Apr;87:103-106. doi: 10.1016/j.seizure.2021.03.010. Epub 2021 Mar 15.
Sudden unexpected death in epilepsy (SUDEP) has been identified as one of the most prevalent causes of mortality in epilepsy, and SUDEP has consequently become an important topic of research. The causes appear multifactorial, including epilepsy-induced cardiac arrest. Current understanding of autopsy negative sudden unexplained death (SUD) in general population and its relation to sudden arrhythmic death syndrome (SADS) could shed some light in SUDEP. Mutual attention to the findings of sudden death in cardiology and epilepsy are discussed here. We performed a narrative review on SUDEP, epilepsy and molecular/genetic autopsy in this population. A proposal of an extended terminology for SUDEP classification is discussed in light of recent issues related to molecular autopsy and genetics. The extended classification might be a step forward in research protocols and a tool for better understanding SUDEP.
癫痫相关性猝死（SUDEP）已被确定为癫痫最常见的致死原因之一，因此成为研究的重点。病因似乎是多因素的，包括癫痫引起的心脏骤停。目前对一般人群中尸检阴性的不明原因猝死（SUD）及其与心律失常性猝死综合征（SADS）的关系的认识，可以为 SUDEP 提供一些线索。本文讨论了心脏病学和癫痫领域对猝死研究结果的关注。我们对该人群中的 SUDEP、癫痫和分子/遗传学尸检进行了叙述性综述。根据分子尸检和遗传学的最新问题，讨论了 SUDEP 分类的扩展术语建议。该扩展分类可能是研究方案的一个进步，也是更好地理解 SUDEP 的工具。
