Li Chuang, Zhao Zixuan, Zhou Jun, Liu Ying, Wang Hao, Zhao Xinhan
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of Interventional Therapy, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, China.
Oncotarget. 2017 Jun 6;8(34):56932-56941. doi: 10.18632/oncotarget.18378. eCollection 2017 Aug 22.
Colorectal cancer (CRC) is one of the most common diseases worldwide, and telomere length has been reported correlate with CRC. This study aimed to investigate whether polymorphisms of telomere length related genes are associated with susceptibility to CRC in Chinese Han population. 11 SNPs from , and genes were selected and genotyped, in addition odds ratio (OR) and 95% confidence intervals (CI) were used to evaluate association between the SNPs and CRC risk in 247 patients clinically and 300 controls in a Chinese Han population. Our results showed that minor allele "G" of rs7708392 and minor allele "C" of rs10036748 in gene were significantly associated with an increased the CRC risk in genotype model, dominant model and additive model after Bonferroni's multiple adjusted (<0.0011). Moreover, the two SNPs rs7708392 and rs10036748 were in strong linkage disequilibrium. We observed that the haplotype "G-C" was more frequent among CRC patients and associated with a 1.58-fold increased CRC risk (95%CI=1.17-2.13, =0.003). Contrarily, haplotype "C-T" was associated with a 0.63-fold reduced CRC risk (95%CI=0.47-0.86, =0.003). Additionally, SNPs in this study except rs7708392 and rs10036748 were found a modest connection with CRC risk. In conclusion, our study firstly provides evidence for a novel association between polymorphisms of telomere length related gene and CRC susceptibility in Chinese Han population, and the results need a further identification in a large sample size and other populations.
结直肠癌（CRC）是全球最常见的疾病之一，据报道端粒长度与结直肠癌相关。本研究旨在探讨端粒长度相关基因的多态性是否与中国汉族人群患结直肠癌的易感性有关。从 、 和 基因中选择了11个单核苷酸多态性（SNP）进行基因分型，此外，采用优势比（OR）和95%置信区间（CI）评估247例临床结直肠癌患者和300例中国汉族对照人群中SNP与结直肠癌风险的关联。我们的结果显示，在Bonferroni多重校正后（<0.0011）， 基因中rs7708392的次要等位基因“G”和rs10036748的次要等位基因“C”在基因型模型、显性模型和加性模型中均与结直肠癌风险增加显著相关。此外，rs7708392和rs10036748这两个SNP处于强连锁不平衡状态。我们观察到，单倍型“G-C”在结直肠癌患者中更为常见，且与结直肠癌风险增加1.58倍相关（95%CI=1.17-2.13， =0.003）。相反，单倍型“C-T”与结直肠癌风险降低0.63倍相关（95%CI=0.47-0.86， =0.003）。此外，本研究中除rs7708392和rs10036748外的SNP与结直肠癌风险存在适度关联。总之，我们的研究首次为中国汉族人群中端粒长度相关 基因多态性与结直肠癌易感性之间的新关联提供了证据，其结果需要在大样本量和其他人群中进一步验证。
