College of basic medicine, Chengdu university of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Medicine (Baltimore). 2021 Mar 26;100(12):e25267. doi: 10.1097/MD.0000000000025267.
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive deposition of fat in hepatocytes except for alcohol and other specific hepatic factors. Xiaochaihu decoction (XD) has been widely used to treat NAFLD in China. However, there is no systematic review found. In order to evaluate the efficacy and safety of XD in the treatment of NAFLS, we need to conduct a meta-analysis and systematic evaluation.
There are enrolled randomized controlled trials (RCTs) evaluating the effectiveness and safety of XD in the treatment of NAFLD. Data come mainly from 4 Chinese databases (CNKI, CBM, Wanfang, and VIP Database) and 4 English databases (Pubmed, Embase, Cochrane Library, and Web of science). The enrollment of RCTs is from the starting date of database establishment till September 30, 2021. The work such as selection of literature, data collection, quality evaluation of included literature, and assessment of publication bias will be conducted by 2 independent researchers. Meta-analysis will be performed by RevMan 5.0 software.
This study will provide high-quality evidence for the effectiveness and safety of XD in the treatment of NAFLD.
The results of the study will help us determine whether XD can effectively treat NAFLD.
This study does not require ethical approval. We will disseminate our findings by publishing results in a peer-reviewed journal.
DOI 10.17605/OSF.IO/A5XEM.
非酒精性脂肪性肝病（NAFLD）是一种临床病理综合征，其特征是除酒精和其他特定肝因素外，肝细胞内脂肪过度沉积。小柴胡汤（XD）已在中国广泛用于治疗 NAFLD。然而，目前尚未发现系统评价。为了评估 XD 治疗 NAFLS 的疗效和安全性，我们需要进行荟萃分析和系统评价。
本研究纳入了评估 XD 治疗 NAFLD 有效性和安全性的随机对照试验（RCTs）。数据主要来自 4 个中文数据库（CNKI、CBM、万方和 VIP 数据库）和 4 个英文数据库（PubMed、Embase、Cochrane 图书馆和 Web of science）。RCT 的纳入时间从数据库建立的起始日期到 2021 年 9 月 30 日。两名独立研究人员将进行文献选择、数据收集、纳入文献质量评价和发表偏倚评估等工作。Meta 分析将使用 RevMan 5.0 软件进行。
本研究将为 XD 治疗 NAFLD 的有效性和安全性提供高质量的证据。
研究结果将有助于我们确定 XD 是否能有效治疗 NAFLD。
本研究无需伦理批准。我们将通过在同行评议的期刊上发表研究结果来传播我们的发现。
OSF 注册号：DOI 10.17605/OSF.IO/A5XEM。
