Koopmans R T, Gribnau F W
Huize St. Joachim en Anna, Nijmegen.
Tijdschr Gerontol Geriatr. 1988 Apr;19(2):55-60.
In this study the need for long-term diuretic therapy was investigated in nursing home patients. In 24 patients the need for diuretics was reassessed and the therapy was discontinued if possible. In 17 of the 24 patients therapy was discontinued. There was a follow-up of 17 days. Four patients developed congestive heart failure, and one patient died during the observation period after a series of complicating events. In the remaining 12 patients therapy had been discontinued successfully. Their mean body weight rose with 0.5 kg, and there were no significant changes in physical examination, serum creatinine, urea, potassium and hematocrit. It was concluded that it was possible in a substantial part of the population studied to discontinue diuretics, when there was no obvious current indication for this treatment. Careful clinical observation is needed to guarantee early detection of (recidive of) congestive heart-failure or hypertension.
在本研究中,对疗养院患者长期利尿治疗的必要性进行了调查。对24例患者重新评估了使用利尿剂的必要性,并尽可能停用该治疗。24例患者中有17例停用了治疗。进行了为期17天的随访。4例患者出现充血性心力衰竭,1例患者在一系列并发症发生后的观察期内死亡。其余12例患者的治疗已成功停用。他们的平均体重增加了0.5千克,体格检查、血清肌酐、尿素、钾和血细胞比容均无显著变化。得出的结论是,在所研究的相当一部分人群中,当目前没有明显的治疗指征时,可以停用利尿剂。需要仔细的临床观察以确保早期发现充血性心力衰竭或高血压(复发)。