Faculty of Science and Engineering, University of Nottingham Malaysia, 43500, Semenyih, Selangor, Malaysia.
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, 43900, Sepang, Selangor, Malaysia.
J Biomed Sci. 2021 Mar 25;28(1):21. doi: 10.1186/s12929-021-00715-9.
Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional modification of multiple downstream genes. Autophagy is a conserved cellular catabolic activity that aims to provide nutrients and degrade un-usable macromolecules in mammalian cells. A number of in vitro, in vivo and clinical studies have reported that some miRNAs could modulate autophagy activity in human breast cancer cells, and these would influence human breast cancer progression and treatment response. Therefore, this review was aimed to discuss the roles of autophagy-regulating miRNAs in influencing breast cancer development and treatment response. The review would first introduce autophagy types and process, followed by the discussion of the roles of different miRNAs in modulating autophagy in human breast cancer, and to explore how would this miRNA-autophagy regulatory process affect the disease progression or treatment response. Lastly, the potential applications and challenges of utilizing autophagy-regulating miRNAs as breast cancer biomarkers and novel therapeutic agents would be discussed.
乳腺癌是全球女性人群中最常见的实体肿瘤。微小 RNA（miRNA）是一种短的非编码 RNA，可以调节多个下游基因的转录后修饰。自噬是一种保守的细胞分解代谢活性，旨在为哺乳动物细胞提供营养物质并降解无用的大分子。许多体外、体内和临床研究报告称，一些 miRNA 可以调节人类乳腺癌细胞中的自噬活性，这将影响人类乳腺癌的进展和治疗反应。因此，本综述旨在讨论自噬调节 miRNA 在影响乳腺癌发生和治疗反应中的作用。本综述首先将介绍自噬的类型和过程，然后讨论不同 miRNA 在调节人类乳腺癌自噬中的作用，并探讨这种 miRNA 自噬调节过程如何影响疾病进展或治疗反应。最后，将讨论将自噬调节 miRNA 作为乳腺癌生物标志物和新型治疗剂的潜在应用和挑战。
