Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
J Zhejiang Univ Sci B. 2020;21(9):690-702. doi: 10.1631/jzus.B2000076.
Autophagy is a conserved catabolic process characterized by degradation and recycling of cytosolic components or organelles through a lysosome-dependent pathway. It has a complex and close relationship to drug resistance in breast cancer. MicroRNAs (miRNAs) are small noncoding molecules that can influence numerous cellular processes including autophagy, through the posttranscriptional regulation of gene expression. Autophagy is regulated by many proteins and pathways, some of which in turn have been found to be regulated by miRNAs. These miRNAs may affect the drug resistance of breast cancer. Drug resistance is the main cause of distant recurrence, metastasis and death in breast cancer patients. In this review, we summarize the causative relationship between autophagy and drug resistance of breast cancer. The roles of autophagy-related proteins and pathways and their associated miRNAs in drug resistance of breast cancer are also discussed.
自噬是一种保守的分解代谢过程，其特征是通过溶酶体依赖性途径降解和回收细胞质成分或细胞器。它与乳腺癌的耐药性有复杂而密切的关系。microRNAs（miRNAs）是小的非编码分子，可以通过基因表达的转录后调控来影响包括自噬在内的许多细胞过程。自噬受到许多蛋白质和途径的调节，其中一些途径反过来又被发现受到 miRNAs 的调节。这些 miRNAs 可能会影响乳腺癌的耐药性。耐药性是乳腺癌患者远处复发、转移和死亡的主要原因。在这篇综述中，我们总结了自噬与乳腺癌耐药性之间的因果关系。还讨论了自噬相关蛋白和途径及其相关 miRNAs 在乳腺癌耐药性中的作用。
